Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma

Blood Advances
Reid W MerrymanScott J Rodig

Abstract

Classical Hodgkin lymphoma (cHL) is characterized by nearly universal genetic alterations in 9p24.1, resulting in constitutive expression of PD-1 ligands. This likely underlies the unique sensitivity of cHL to PD-1 blockade, with response rates of ∼70% in relapsed/refractory disease. There are now numerous clinical trials testing PD-1 inhibitors in earlier stages of treatment and in combination with many other therapies. In general, non-Hodgkin lymphomas (NHLs) do not display a high frequency of 9p24.1 alterations and do not share cHL's vulnerability to PD-1 blockade. However, a few entities have genetic or immunologic features that may predict sensitivity to immune checkpoint blockade. These include primary mediastinal B cell lymphoma, primary central nervous system lymphoma, and primary testicular lymphoma, which harbor frequent alterations in 9p24.1, as well as Epstein Barr virus (EBV)-infected lymphomas, where EBV infection leads to increased PD-L1 expression. Although these subtypes may be specifically vulnerable to PD-1 blockade, the majority of NHLs appear to be minimally sensitive to PD-1 blockade monotherapy. Current investigations in NHL are therefore focusing on targeting other checkpoints or studying PD-1-based comb...Continue Reading

References

Dec 6, 1984·The New England Journal of Medicine·S J Horning, S A Rosenberg
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens M ChemnitzJames L Riley
Oct 16, 2004·Immunity·Ching-Tai HuangDario A A Vignali
Mar 18, 2005·Annual Review of Immunology·Tania H Watts
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary E KeirArlene H Sharpe
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raanan BergerArnon Nagler
Aug 9, 2008·The New England Journal of Medicine·Bruce D Cheson, John P Leonard
Dec 17, 2008·Nature Reviews. Cancer·Ralf Küppers
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joaquim CarrerasElias Campo
Oct 8, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen M AnsellJohn M Timmerman
Mar 12, 2010·The New England Journal of Medicine·Christian SteidlRandy D Gascoyne
May 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J AndorskyJohn M Timmerman
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Franziska C EberleElaine S Jaffe
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael R GreenMargaret A Shipp
May 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin J ChenScott J Rodig
Apr 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jacob P SmeltzerStephen M Ansell
Dec 9, 2014·The New England Journal of Medicine·Stephen M AnsellPhilippe Armand
Jun 2, 2015·The New England Journal of Medicine·James LarkinJedd D Wolchok
Feb 7, 2016·Genes, Chromosomes & Cancer·Katrien Van RoosbroeckIwona Wlodarska
Apr 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Margaretha G M RoemerMargaret A Shipp
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander M LesokhinJohn Timmerman
Jun 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philippe ArmandCraig H Moskowitz
Apr 26, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert ChenUNKNOWN KEYNOTE-087

❮ Previous
Next ❯

Citations

Aug 23, 2018·Virchows Archiv : an International Journal of Pathology·Thomas Menter, Alexandar Tzankov
Aug 29, 2019·Expert Opinion on Biological Therapy·Semira Sheikh, John Kuruvilla
Feb 12, 2019·Drugs·Sheridan M Hoy
Aug 21, 2018·Current Opinion in Oncology·Juan MontoroManuel Guerreiro
May 20, 2020·Leukemia & Lymphoma·Lucy PickardJessica Okosun
May 21, 2020·British Journal of Haematology·Nicole A CarreauCatherine Diefenbach
Jun 14, 2020·Cancer·Seth J Rotz, Christopher E Dandoy
Aug 16, 2019·Physiological Reviews·Carla Riera-DomingoMassimiliano Mazzone
Jul 8, 2020·European Journal of Haematology·Marjukka PollariSirpa Leppä
May 3, 2018·Frontiers in Oncology·Semir VranicAla-Eddin Al Moustafa
Mar 23, 2018·Frontiers in Oncology·Thomas Menter, Alexandar Tzankov
Sep 12, 2018·Cancer Immunology, Immunotherapy : CII·Alexander N R WeberOlaf-Oliver Wolz
Jun 8, 2018·Clinical and Experimental Medicine·Amro Mohamed Sedky El-GhammazMohamad Ayed Mohamad
Sep 2, 2018·Molecular and Cellular Pediatrics·Stefan E G BurdachKlaus-Michael Debatin
Mar 13, 2020·Protein & Cell·Xiaoguang WangJing H Wang
Sep 14, 2018·The American Journal of Surgical Pathology·Bo-Jung ChenLeticia Quintanilla-Martinez
May 18, 2020·Journal for Immunotherapy of Cancer·Karoline EhlertHolger Lode
Sep 1, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Pottayil G Sasikumar, Murali Ramachandra
Jan 10, 2020·Blood Advances·Matthew J FrigaultRobin M Joyce
Feb 2, 2018·Journal of Hematology & Oncology·Xin LiKen H Young
Nov 16, 2019·Cancer Discovery·Ankur K NagarajaAdam J Bass
Jan 13, 2021·Cancers·Marc ArmengolGaël Roué
Dec 10, 2020·Journal of Immunology Research·Maansi Joshi, Stephen M Ansell
May 28, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sairah AhmedMehdi Hamadani
Apr 4, 2021·Journal of Personalized Medicine·Cristina FerrariGiuseppe Rubini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

© 2022 Meta ULC. All rights reserved