Checkpoint blockade inhibitors enhances the effectiveness of a Listeria monocytogenes -based melanoma vaccine

Oncotarget
Ryan P Gilley, Peter H Dube

Abstract

Melanoma continues to be a significant health concern worldwide despite recent improvements in treatment. Unlike many other prominent cancers, melanoma incidence in both men and women increased over the past decade in the U. S. and much of the developed world. The single greatest risk factor for melanoma is damage from ultraviolet radiation associated with lifestyle. The lifestyle component suggests that although melanoma risk can be minimized with behavioral changes, vaccinating high-risk individuals against melanoma may be the most efficacious preventative method. Accordingly, using a highly attenuated, double-mutant L. monocytogenes strain expressing a tumor-associated antigen, we obtained significant protection against melanoma in a mouse model. The Listeria-based vaccine induced protection through antigen-specific CD8+ T-cells inducing both a protective primary and a memory T-cell response. Vaccinated animals were significantly protected from melanoma. When used in conjunction with checkpoint blockade treatment, the vaccine substantially reduced tumor size and number relative to animals receiving checkpoint blockade (CPB) alone. This study provides evidence that CPB treatment synergizes with a L. monocytogenes-based melano...Continue Reading

References

Nov 1, 1976·Journal of the National Cancer Institute·I J Fidler, G L Nicolson
Apr 1, 1992·Infection and Immunity·D A PortnoyP Cossart
Jun 1, 1992·The Journal of Experimental Medicine·J T Harty, M J Bevan
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Apr 1, 1988·The Journal of Experimental Medicine·D A PortnoyD J Hinrichs
Jul 16, 1987·Nature·J F BrunetP Golstein
Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H W HerrH F Oettgen
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Jan 17, 1996·Journal of the National Cancer Institute·N P RestifoS A Rosenberg
Jun 1, 1996·The Journal of Experimental Medicine·M F Krummel, J P Allison
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Jun 11, 1999·The Journal of Biological Chemistry·R SchwandnerC J Kirschning
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·C A Chambers, J P Allison
May 19, 2001·International Immunopharmacology·O Takeuchi, S Akira
Sep 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dirk G BrockstedtThomas W Dubensky
Mar 17, 2006·Cancer Research·Tong-xin XieSuyun Huang
Apr 12, 2006·The Journal of Experimental Medicine·Mary E KeirArlene H Sharpe
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Aug 28, 2007·Microbes and Infection·Kevin W BruhnJeff F Miller
Feb 15, 2008·Cancer Immunology, Immunotherapy : CII·Vafa ShahabiPaulo Maciag
Mar 10, 2010·Cancer Immunology, Immunotherapy : CII·Laurence M WoodYvonne Paterson
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Aug 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pei-Yi LinTyler J Curiel
Dec 8, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dung T LeDaniel A Laheru
Sep 24, 2013·Lancet·Alexander M M EggermontCaroline Robert
Jan 1, 2013·Journal for Immunotherapy of Cancer·Mikayel MkrtichyanSamir N Khleif
May 27, 2014·Frontiers in Cellular and Infection Microbiology·Laurence M Wood, Yvonne Paterson
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Lori Cory, Christina Chu
Jun 9, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Haiqian ShenPeter H Dube
Nov 9, 2017·Annals of Translational Medicine·Marcos VasquezPedro Berraondo

❮ Previous
Next ❯

Citations

May 4, 2021·Frontiers in Immunology·Mariam OladejoLaurence M Wood
Jun 14, 2021·Seminars in Cancer Biology·Muhammad Jameel Mughal, Hang Fai Kwok

❮ Previous
Next ❯

Methods Mentioned

BETA
FACS
flow cytometry

Software Mentioned

Graphpad Prisim

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

International Journal of Women's Dermatology
Mi Ryung RohHensin Tsao
The Journal of Investigative Dermatology
Noah CraftJeff F Miller
© 2021 Meta ULC. All rights reserved