Checkpoint control: the journey continues

Current Biology : CB
Jan-Michael Peters


Mad2 and p31(comet) are components of the spindle assembly checkpoint which controls the fidelity of chromosome segregation. Two recent structural studies reveal new insight into how these proteins achieve this difficult task.


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Nov 29, 2002·The EMBO Journal·Toshiyuki HabuTomohiro Matsumoto
Mar 17, 2004·Nature Structural & Molecular Biology·Xuelian LuoHongtao Yu
Feb 8, 2005·Current Biology : CB·Anna De AntoniAndrea Musacchio
Mar 31, 2005·Cell·Kim Nasmyth
Mar 10, 2006·The EMBO Journal·Marina MapelliAndrea Musacchio
Aug 10, 2006·Nature Reviews. Molecular Cell Biology·Jan-Michael Peters
Nov 21, 2007·Cell·Maojun YangXuelian Luo

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Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.