Checkpoint control: the journey continues

Current Biology : CB
Jan-Michael Peters

Abstract

Mad2 and p31(comet) are components of the spindle assembly checkpoint which controls the fidelity of chromosome segregation. Two recent structural studies reveal new insight into how these proteins achieve this difficult task.

Citations

Mar 7, 1998·Science·L H HwangA W Murray
Nov 29, 2002·The EMBO Journal·Toshiyuki HabuTomohiro Matsumoto
Mar 17, 2004·Nature Structural & Molecular Biology·Xuelian LuoHongtao Yu
Feb 8, 2005·Current Biology : CB·Anna De AntoniAndrea Musacchio
Mar 31, 2005·Cell·Kim Nasmyth
Mar 10, 2006·The EMBO Journal·Marina MapelliAndrea Musacchio
Aug 10, 2006·Nature Reviews. Molecular Cell Biology·Jan-Michael Peters
Nov 21, 2007·Cell·Maojun YangXuelian Luo

Related Concepts

Spindle
Cell Cycle Proteins
MAD2L1 protein, human
Mitotic Spindle Apparatus
Complex (molecular entity)
MAD1L1 gene
MXD1 gene
MAD2L1BP protein, human
Staphylococcal Protein A
MXI1 wt Allele

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.