Checkpoint inhibition and melanoma: Considerations in treating the older adult

Journal of Geriatric Oncology
Claire F Friedman, Jedd D Wolchok

Abstract

The incidence of melanoma and associated mortality rate from advanced disease in older adults is increasing over time. Checkpoint inhibitors have demonstrated a survival benefit for the treatment of stage IV or unresectable stage III disease and have become one of the standards of care. Data suggests that adults aged 65 and older benefit from treatment with checkpoint inhibitors without an increased incidence in adverse events. However, clinicians should be aware of the potential side effects of this class of medications and how to manage them in older adults.

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Citations

Oct 3, 2017·Aging and Disease·Simone GarcovichKetty Peris
May 13, 2020·International Journal of Clinical Oncology·Kazuyuki NumakuraTomonori Habuchi
May 10, 2020·British Journal of Clinical Pharmacology·Vishal NavaniAndre Van Der Westhuizen
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Jan 12, 2021·Asia-Pacific Journal of Oncology Nursing·Matthew D BiniakewitzKristen L Fessele

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