Mar 27, 2019

Checkpoint inhibition immunotherapy for advanced local and systemic conjunctival melanoma: a clinical case series

Journal for Immunotherapy of Cancer
Paul T Finger, Anna C Pavlick

Abstract

Herein, we describe the use of systemic immunotherapy for both locally advanced and metastatic conjunctival melanoma. Current treatments for advanced conjunctival melanoma typically result in poor local control leading to disfiguring orbital exenteration surgery. Locoregional spread of conjunctival malignant melanoma typically requires pre-auricular and cervical lymph node dissection with post-operative adjuvant radiation therapy. In addition, classic systemic chemotherapy has been unsuccessful in the treatment of metastatic disease. This is a retrospectively analyzed clinical case series of 5 patients with biopsy proven conjunctival melanoma who were treated with checkpoint inhibition therapy. Of these, 3 patients were treated for residual ocular disease present after failing multiple local therapies and refusing orbital exenteration surgery and two (with local ocular control) for metastatic conjunctival melanoma. Both those with locally advanced disease and patients with metastatic disease received an anti-PD1 agent in combination with another immunotherapeutic agent. All 5 were given multiple cycles of systemic anti-PD1 therapy, 1 was initially treated with single agent ipilimumab (3 mg/kg) prior to approval of anti-PD1 agen...Continue Reading

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Mentioned in this Paper

Vision
Metastatic Melanoma
Systemic Disease
Malignant Tumor of Colon
Ophthalmic Examination and Evaluation
ipilimumab
Adverse Effects
Local Therapy
Evaluation
Colitis

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