Checkpoint inhibitor-induced uveitis: a case series

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Christopher D ConradyAjay Singh

Abstract

Checkpoint inhibitors are now a common treatment modality for metastatic cancer. In this manuscript, we describe the clinical features and management of autoimmune non-infectious uveitis induced by this class of drugs. Seven patients undergoing checkpoint inhibitor treatment for metastatic cancer from uveitis practices at three tertiary referral centers. All seven patients developed various severities of ocular inflammatory disease while taking checkpoint inhibitors for metastatic disease. Checkpoint inhibitors may induce autoimmune uveitis. Ocular complaints should prompt an early evaluation by an ophthalmologist.

References

Dec 18, 1998·Science·K M LeeJ A Bluestone
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
May 25, 2005·International Journal of Cancer. Journal International Du Cancer·Elisabetta ContardiMaria Pia Pistillo
Sep 16, 2006·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Nov 15, 2008·The Oncologist·Jedd D Wolchok, Yvonne Saenger
Sep 3, 2010·The Journal of Clinical Investigation·Rachel R Caspi
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Mar 22, 2013·Journal of Ophthalmic Inflammation and Infection·Rim KahlounMoncef Khairallah
Jul 19, 2014·American Journal of Ophthalmology·Christina H ChoeRavi K Amaravadi
Feb 14, 2015·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Elisabetta MiserocchiGiulio M Modorati
Mar 11, 2015·Therapeutic Advances in Medical Oncology·Sarah J Welsh, Pippa G Corrie
Mar 24, 2015·Trends in Immunology·Kristen E Pauken, E John Wherry
Jun 17, 2015·Journal of Ophthalmic Inflammation and Infection·Dafina DraganovaFrançois Willermain
Aug 5, 2016·Retinal Cases & Brief Reports·Michael T Aaberg, Thomas M Aaberg
Aug 27, 2016·Annals of Translational Medicine·Helena Linardou, Helen Gogas
Sep 7, 2016·Ocular Immunology and Inflammation·Justin KarlinJeffrey Golen
Dec 20, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mario MandalàDaniela Massi

❮ Previous
Next ❯

Citations

May 24, 2018·Arthritis & Rheumatology·James T Rosenbaum, Andrew D Dick
Sep 18, 2018·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Mar 14, 2019·The New England Journal of Medicine·James T RosenbaumMai P Hoang
Mar 14, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·John A ThompsonJillian L Scavone
Apr 24, 2019·Ocular Immunology and Inflammation·Masaaki YoshidaToru Nakazawa
Aug 15, 2019·The British Journal of Ophthalmology·Arthi Ganesh VenkatSunil Srivastava
May 17, 2019·Nature Reviews. Clinical Oncology·Filipe MartinsMichel Obeid
Jul 10, 2020·Ocular Immunology and Inflammation·Ruby A ParikhMeghan K Berkenstock
Sep 19, 2019·Journal of Current Ophthalmology·Tony FangMahyar Etminan
Jul 2, 2019·Ocular Immunology and Inflammation·Junwon LeeChristopher Seungkyu Lee
Jun 20, 2020·Cancer Immunology, Immunotherapy : CII·Yong Joon KimChristopher Seungkyu Lee
Aug 23, 2020·Indian Journal of Ophthalmology·Manisha AgarwalBahram Bodaghi
Jan 5, 2021·Cornea·Anaïs RamaekersKarolien Termote
Dec 30, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Florentia DimitriouMartin Urner
Feb 5, 2021·Ocular Immunology and Inflammation·Parsa Mehraban FarTodd Urton
Jan 14, 2021·Survey of Ophthalmology·Maram E A Abdalla Elsayed, Igor Kozak
Jan 14, 2021·Survey of Ophthalmology·Carmen Alba-Linero, Emilio Alba
Nov 25, 2020·Cancers·Maria-Carlota Londoño On Behalf Of The Retoinmuno Multidisciplinary Group
Feb 27, 2021·Therapeutic Advances in Medical Oncology·Orthi ShahzadPhilippa Corrie
Oct 5, 2020·Tuberculosis·Soumyava BasuNarsing A Rao
Apr 1, 2021·Drugs·Blake H FortesLauren A Dalvin
Apr 2, 2021·Ocular Immunology and Inflammation·Eliot R DowEdmund Tsui
Feb 18, 2019·American Journal of Ophthalmology·Karen BittonAntoine Rousseau
Jun 18, 2020·Ocular Immunology and Inflammation·Iris Deitch-HarelMichal Kramer
May 14, 2021·Ocular Immunology and Inflammation·Stephan ThurauGerhild Wildner
Jun 15, 2021·American Journal of Ophthalmology Case Reports·Julia CanestraroJasmine H Francis
Oct 29, 2021·Immunotherapy·Christine FardeauBénédicte Lebrun-Vignes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Archivos de la Sociedad Española de Oftalmología
J Cano-Parra, M Díaz-Llopis
Mayo Clinic Proceedings
Naiara S BarbosaUma Thanarajasingam
© 2022 Meta ULC. All rights reserved