Checkpoint inhibitor treatment induces an increase in HbA1c in nondiabetic patients

Melanoma Research
Marie-Léa GauciPATIO group

Abstract

Immunotherapy greatly improves clinical outcomes in treated patients with cancer. However, the long-lasting immune response and long duration of therapy could induce long-term adverse effects owing to the chronic inflammation induced. Type 2 diabetes is now recognized as an inflammatory disease. In addition, immunotherapy is concerned with increase in the production of tumor necrosis factor-α, interleukin-2, and interferon-γ, which are involved in the inflammatory process. Based on these observations, we hypothesized that anti-programmed cell death-1 (anti-PD-1) and/or anticytotoxic T-lymphocyte-associated protein-4 therapy could contribute to type 2 diabetes genesis in treated patients. Therefore, to evaluate this hypothesis, we studied HbA1c levels during follow-up in patients treated with anti-PD-1 and/or anticytotoxic T-lymphocyte-associated protein-4 therapy. A prospective and observational study was performed in an oncodermatology department (Saint-Louis Hospital, Paris, France) from March 2015 to February 2017. Sixty-two patients meeting the inclusion criteria were enrolled. Forty-three patients had paired HbA1c measurements during their follow-up period and were analyzed. The median follow-up was 3 months. We noted an i...Continue Reading

References

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Citations

Aug 20, 2019·Acta Diabetologica·Lucien MarchandChristine Cugnet-Anceau
Jan 3, 2020·The Journal of Clinical Investigation·Michael Dougan, Massimo Pietropaolo

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

R
R Foundation for Statistical Computing

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