Checkpoint signalling: Mad2 conformers and signal propagation

Current Biology : CB
Kevin G Hardwick

Abstract

The spindle checkpoint protein Mad2 has a tendency to form multimers and adopts at least two structural conformations. New work highlights the importance of the Mad2-Mad2 interaction, and suggests how spindle checkpoint signals are propagated away from kinetochores.

References

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Apr 25, 2006·Current Biology : CB·Martin VinkAndrea Musacchio
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Citations

Mar 7, 1998·Science·L H HwangA W Murray
Oct 24, 1998·The Journal of Cell Biology·R H ChenA W Murray
Mar 8, 2000·The Journal of Cell Biology·Kevin G HardwickA W Murray
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Kevin G Hardwick
Mar 17, 2004·Nature Structural & Molecular Biology·Xuelian LuoHongtao Yu
Jun 9, 2004·Current Biology : CB·Bonnie J HowellEdward D Salmon
Feb 8, 2005·Current Biology : CB·Anna De AntoniAndrea Musacchio

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