PMID: 70526Aug 1, 1977

Chelates of dicumarol I: Preparation and structure identification of magnesium chelate

Journal of Pharmaceutical Sciences
L D Bighley, R J Spivey

Abstract

A magnesium chelate of dicumarol was prepared by reacting a suspension of dicumarol and magnesium oxide in 50% water-methanol. GLC, thermogravimetric, and elemental analyses showed that this compound has a 2:1 ligand-metal stoichiometry with 2 moles of water associated with the complex. Although the chelate does not melt, two endothermic peaks at 205 and 274 degrees were observed in the thermogram, in contrast to a single endothermic peak corresponding to a melting point of 288 degrees for dicumarol. IR spectroscopy indicated that the magnesium is bonded between the carbonyl at C-2 and the oxygen at C-4' (or vice versa).

References

Sep 1, 1970·Journal of Pharmaceutical Sciences·J L Lach, L D Bighley
Mar 1, 1973·Journal of Pharmaceutical Sciences·M J AkersL J Fischer
Jun 1, 1969·Tetrahedron·D W Hutchinson, J A Tomlinson

Citations

Jan 1, 1985·Reviews on Drug Metabolism and Drug Interactions·P F D'Arcy, J C McElnay
Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·P F D'Arcy, J C McElnay

Related Concepts

Dicoumarin
Vitreous Carbon
Chromatography, Gas-Liquid
Densitometry
Differential Thermal Analysis
Hydrogen
Magnesium
In Vivo NMR Spectroscopy
Spectrophotometry, Atomic
Infrared Spectrophotometry

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