PMID: 11605171Oct 18, 2001Paper

Chelation therapy in beta-thalassemia: an optimistic update

Seminars in Hematology
P J Giardina, R W Grady

Abstract

Iron chelation therapy with desferrioxamine (DFO) has dramatically improved the outlook in beta-thalassemia. Parenteral DFO reduces tissue iron stores, prevents iron-induced organ damage, and reduces morbidity and mortality, with little serious toxicity. However, the burden of prolonged subcutaneous portable pump infusions, high cost, and patient noncompliance have prompted the development of new methods of administration and new formulations of DFO as well as oral iron chelators. Deferiprone (L1), the only oral iron chelator studied in large long-term clinical trials, is less effective and more toxic than DFO and may not adequately control iron overload; however, compliance and quality of life are improved. Combinations of two iron chelators (such as parenteral DFO plus oral L1, or 2,3-DHB; or oral L1 plus HBED) have been shown to produce additive and synergistic effects, explained by the shuttle hypothesis. Iron bound to a "shuttle"--an oral agent that mobilizes tissue iron--is exchanged in the bloodstream with a "sink"--such as parenteral DFO--and excreted via the kidneys, while the shuttle is reutilized. Combination therapy may produce enhanced iron excretion, target specific iron compartments, minimize side effects, increa...Continue Reading

Citations

Jul 4, 2003·Chirality·Raymond J BergeronKhalil A Abboud
Nov 6, 2002·International Journal of Hematology·Robert S BrittonBruce R Bacon
Mar 21, 2008·Annals of Hematology·Amal El-BeshlawyAli Taher
Oct 23, 2004·Best Practice & Research. Clinical Haematology·Michel SadelainIsabelle Rivière
Mar 2, 2005·Best Practice & Research. Clinical Haematology·Z Ioav CabantchikP Cianciulli
Jun 15, 2007·Journal of Medicinal Chemistry·Raymond J BergeronJames R Rocca
Aug 15, 2012·Journal of Medicinal Chemistry·Raymond J BergeronJames S McManis
Jun 7, 2008·Journal of Medicinal Chemistry·Raymond J BergeronShailendra Singh
Sep 16, 2008·Journal of Medicinal Chemistry·Raymond J BergeronShailendra Singh
Sep 7, 2007·Journal of Pediatric Hematology/oncology·Athanasios ChristoforidisMiranda Athanassiou-Metaxa
Apr 4, 2006·Environmental Health Perspectives·Shawn A HamidiniaDouglas R Pfeiffer
Nov 1, 2012·Journal of Blood Medicine·Vasilios BerdoukasThomas Coates
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Laura BredaStefano Rivella
Jul 9, 2014·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Hamdy A IbrahimRania A Abd Elazim
Oct 26, 2012·Analytical and Bioanalytical Chemistry·Guido CrisponiAndrea Tapparo
May 29, 2010·Advances in Hematology·Luca MelchioriStefano Rivella
Nov 26, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Raymond J BergeronShailendra Singh
Jan 18, 2011·Free Radical Biology & Medicine·Evangelia VlachodimitropoulouRichard J Naftalin
Nov 16, 2010·Hematology/oncology Clinics of North America·Vijay G Sankaran, David G Nathan
Jul 16, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Patricia EvansJohn B Porter
Dec 13, 2005·Annals of the New York Academy of Sciences·Antonis Kattamis
Dec 13, 2005·Annals of the New York Academy of Sciences·David G Nathan
Dec 13, 2005·Annals of the New York Academy of Sciences·Michel SadelainIsabelle Riviere
Sep 13, 2006·British Journal of Haematology·Athanasios ChristoforidisMiranda Athanassiou-Metaxa
Apr 16, 2008·British Journal of Haematology·Leszek Lisowski, Michel Sadelain
May 20, 2011·Journal of Clinical Pharmacy and Therapeutics·L B JordanM S Duh
Aug 18, 2010·Annals of the New York Academy of Sciences·Sara GardenghiStefano Rivella
Mar 13, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Ali AycicekMahmut Abuhandan
Aug 26, 2006·Diabetes Research and Clinical Practice·Athanasios ChristoforidisMiranda Athanassiou-Metaxa
Jan 3, 2006·Blood Cells, Molecules & Diseases·Antonis KattamisChristos Kattamis
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Adriana CeciDomenico De Mattia
Dec 4, 2003·Expert Opinion on Pharmacotherapy·Karen F MurrayKris V Kowdley
Apr 1, 2011·Expert Opinion on Therapeutic Patents·Hossein HeliKhashayar Karimian
Jan 30, 2015·The Journal of Pharmacy and Pharmacology·Kanjana PangjitSomdet Srichairatanakool

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