Chemerin and Cancer

International Journal of Molecular Sciences
Oliver TreeckOlaf Ortmann

Abstract

Chemerin is a multifunctional adipokine with established roles in inflammation, adipogenesis and glucose homeostasis. Increasing evidence suggest an important function of chemerin in cancer. Chemerin's main cellular receptors, chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and C-C chemokine receptor-like 2 (CCRL2) are expressed in most normal and tumor tissues. Chemerin's role in cancer is considered controversial, since it is able to exert both anti-tumoral and tumor-promoting effects, which are mediated by different mechanisms like recruiting innate immune defenses or activation of endothelial angiogenesis. For this review article, original research articles on the role of chemerin and its receptors in cancer were considered, which are listed in the PubMed database. Additionally, we included meta-analyses of publicly accessible DNA microarray data to elucidate the association of expression of chemerin and its receptors in tumor tissues with patients' survival.

References

Aug 8, 1997·The Journal of Biological Chemistry·P NairV M Rangnekar
Apr 13, 2000·International Review of Cytology·C S Teng
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anja Krones-HerzigDan Mercola
Oct 8, 2003·The Journal of Experimental Medicine·Valérie WittamerDavid Communi
Oct 14, 2003·Oncogene·Mario MikulaWolfgang Mikulits
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian A ZabelEugene C Butcher
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·F Gregory BuchananRaymond N DuBois
Jul 20, 2007·The Journal of Biological Chemistry·Kerry B GoralskiChristopher J Sinal
Oct 3, 2007·Cancer Research·Xiaoping ZhangAria F Olumi
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandeep K RaghuwanshiRicardo M Richardson
Sep 17, 2008·Archives of Surgery·Gustavo G Fernandez-RanvierElectron Kebebew
Jan 5, 2010·Biochemical and Biophysical Research Communications·Jaspreet KaurHarpal S Randeva
Mar 20, 2010·The Journal of Clinical Endocrinology and Metabolism·Kiymet BozaogluJeremy B M Jowett
Nov 29, 2011·Cytokine & Growth Factor Reviews·Benjamin BondueMarc Parmentier
Nov 29, 2011·European Journal of Pharmacology·Luigina GraziosiStefano Fiorucci
Mar 27, 2012·Human Reproduction·Maxime ReverchonJoëlle Dupont
Apr 3, 2012·Journal of Experimental & Clinical Cancer Research : CR·Yoshitaka FujimoriKenichi Sugihara
Jul 4, 2012·The Journal of Experimental Medicine·Russell K PachynskiEugene C Butcher
Dec 12, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J L RourkeC J Sinal
Jun 15, 2013·Stem Cells·Shanmugam MuruganandanChristopher J Sinal
Dec 11, 2013·British Journal of Cancer·L Oliveira-FerrerK Milde-Langosch
Jan 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Safiye Gonzalvo-FeoSilvano Sozzani
Feb 11, 2014·American Journal of Reproductive Immunology : AJRI·Lei LiJian V Zhang
Apr 15, 2014·Cellular & Molecular Immunology·Yuli LinRui He
Jun 21, 2014·Cancer·Mauricio BurottoElise C Kohn
Feb 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magdalena HerováMartin Hersberger
Sep 13, 2015·Molecular and Cellular Endocrinology·Jillian L RourkeChristopher J Sinal
Nov 14, 2015·Molecular Immunology·Parisa SarmadiGunes Esendagli
Apr 20, 2016·British Journal of Cancer·J Dinesh KumarAndrea Varro
May 26, 2016·Obesity·Shwu-Shin ChangLawrence Leung
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Neeraj KumariAnant Narayan Bhatt

❮ Previous
Next ❯

Citations

Feb 6, 2020·International Journal of Molecular Sciences·Christa Buechler
Aug 19, 2020·Biomarkers in Medicine·Xiaolong QiYingjun Li
Jun 21, 2020·International Journal of Environmental Research and Public Health·Anna CzajkowskaŁukasz Małek
Jan 29, 2020·Expert Review of Molecular Diagnostics·José M AmenábarChamindie Punyadeera
Sep 29, 2019·International Journal of Molecular Sciences·Kerry B GoralskiChristopher J Sinal
Oct 3, 2020·International Journal of Molecular Sciences·Susanne FederChrista Buechler
Oct 18, 2020·International Journal of Molecular Sciences·Marlen SpirkChrista Buechler
Oct 28, 2020·Cancers·Oliver Treeck, Christa Buechler
Feb 5, 2021·International Journal of Molecular Sciences·Duc-Vinh Pham, Pil-Hoon Park
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Tiziana SchioppaAnnalisa Del Prete
Feb 17, 2021·Clinical & Experimental Metastasis·Sneha SoniChandi C Mandal
Mar 7, 2021·International Journal of Molecular Sciences·Silvia PeregoGiovanni Lombardi
Mar 24, 2021·Scientific Reports·Yanfang SongDan Wen
May 15, 2021·Frontiers in Pharmacology·Hanyi FangBernadette Marquez-Nostra
Jun 3, 2021·Cancers·Joanna OlszańskaDorota Nowak
Jun 4, 2021·Advances in Medical Sciences·Magdalena Acewicz, Irena Kasacka
Oct 14, 2021·Archives of Physiology and Biochemistry·Zoya TahergorabiMitra Moodi
Jul 7, 2021·Journal of Mammary Gland Biology and Neoplasia·Adelina PlanggerGerhard Hamilton
Jan 14, 2020·Experimental and Molecular Pathology·Paweł KiczmerElżbieta Świętochowska

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
RNAseq

Software Mentioned

GEPIA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.