Chemerin in human cardiovascular disease

Vascular Pharmacology
Jaspreet KaurHarpal S Randeva

Abstract

Adipose tissue, initially known only for storing excess fat, produces a number of active cytokine-like hormones, collectively known as adipokines or adipocytokines. These molecules are further known to elicit auto-, para- and endocrine functions in the body. In healthy bodies, the cardiovascular endothelium maintains vascular health by critically controlling the interplay between various factors. However, in diseased states such as obesity, owing to numerous metabolic malfunctions, this vascular homeostasis is disrupted. The dysregulated metabolic stimuli perturb vascular homeostasis via initiating or exacerbating the pre-existing inflammatory processes. These inflammatory processes further recruit immune cells to the site of injury, alter cell adhesion molecule expression, and reduce Nitric Oxide levels. These altered mechanisms result in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. In this review article, we aim to evaluate the current literature in understanding the role of Chemerin in vascular health and furthermore, its role in maintaining vascular homeostasis with respect to inflammation, obesity and associated Metabolic Syndrome (MetS) risk factors. For over fifteen years, a growing...Continue Reading

Citations

Apr 20, 2019·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Sefer UstebaySuleyman Aydin
Nov 30, 2019·BioMed Research International·Huadong LiuShaohong Dong
Aug 30, 2020·Journal of Clinical Medicine·Adela-Viviana Sitar-TautAngela Cozma
Dec 17, 2020·International Journal of Molecular Sciences·Paweł GutajEwa Wender-Ozegowska
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Apurva ShrivastavaChristian Schulte
Apr 13, 2021·Archives of Physiology and Biochemistry·Ishwarlal Jialal
May 14, 2021·Stroke; a Journal of Cerebral Circulation·Russell YanofskyStella S Daskalopoulou
Jun 4, 2021·Advances in Medical Sciences·Magdalena Acewicz, Irena Kasacka

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