PMID: 2123175Sep 1, 1990Paper

Chemical activation of thin-fiber phrenic afferents: respiratory responses

Journal of Applied Physiology
S N HussainC Roussos

Abstract

In supine chloralose-anesthetized and mechanically ventilated dogs, we assessed the effects of group III and IV thin-fiber phrenic afferents on cardiorespiratory control by injecting capsaicin into the phrenic artery of an in situ isolated and innervated left diaphragm. Inspiratory motor drive was assessed by measuring the electromyogram of left and right diaphragm, left parasternal, and mylohyoid muscles in five protocols. 1) Three boluses (2 ml) of capsaicin (1, 10, and 50 micrograms/ml) were injected 30 min apart. Only the 50-micrograms/ml injection elicited a significant increase in arterial pressure, heart rate, and inspiratory motor drive. 2) Repeated doses of capsaicin were tested. The pressor and hyperpneic responses were weakened. 3) High doses of capsaicin (100 and 500 micrograms/ml) were given. Hyperpneic and pressor responses were similar to those elicited by the 50-micrograms/ml dose. 4) When the left phrenic nerve was sectioned, the pressor and hyperpneic responses to the 50-micrograms/ml injection were abolished. 5) Capsaicin (50 micrograms/ml) was infused into the arterial supply of the in situ vascularly isolated and innervated gastrocnemius. Arterial pressure, breathing frequency, and inspiratory motor drive t...Continue Reading

Citations

Jun 20, 1998·The Journal of Physiology·A D De Troyer
Aug 25, 2017·Journal of Neurophysiology·Jayakrishnan NairDavid D Fuller
Jun 25, 2005·The Journal of Physiology·Yves JammesStéphane Delpierre
May 20, 2003·Journal of Applied Physiology·Joshua R RodmanJerome A Dempsey
Jul 5, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Stephen BartschPhilippe Haouzi
Feb 1, 1996·Intensive Care Medicine·C Roussos, S Zakynthinos
Sep 9, 2006·American Journal of Respiratory and Critical Care Medicine·Spyros ZakynthinosTheodoros Vassilakopoulos
Mar 15, 2001·Journal of Applied Physiology·O E Malakhova, P W Davenport
Jul 6, 2007·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
May 15, 2018·The Journal of Physiology·Joseph F WelchA William Sheel
Oct 12, 1999·The American Journal of Physiology·T VassilakopoulosC Roussos
Nov 18, 2021·Journal of Neurophysiology·Kristi A StreeterDavid D Fuller

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