PMID: 3768419Nov 19, 1986Paper

Chemical alterations of hyaluronic acid and dermatan sulfate detected in aging human skin by infrared spectroscopy

Biochimica Et Biophysica Acta
M O LongasX Y He

Abstract

Age-mediated deacetylation of hyaluronic acid and dermatan sulfate, and shift of sulfate ester configuration were indicated by infrared spectroscopy. Hyaluronic acid and the three dermatan sulfates (DS18, DS28 and DS35), sequentially precipitated from adult skin with 18%, 28% and 35% ethanol, were analyzed at varying ages. At age 75 years, loss of infrared bands in the 1,650-1,600 cm-1 region, at 1,380 cm-1 and 1,320 cm-1 and appearance of a band at 1,560 cm-1 were characteristic of hyaluronic acid and DS35; moreover, in DS28 and DS35 the intensities of the bands at 840 cm-1 and 860 cm-1 were, respectively, decreased and increased. A low intensity band in the 805-785 cm-1 region was observed in the spectra of DS18 (19-35 years), DS28 (70-80 years) and DS35 (all ages). It intensified in DS28 of the 80-year-olds. In the 75 +/- 5-year-old group, ninhydrin-positive material of hyaluronic acid and DS35 increased, while reducing GlcNAc of hyaluronic acid decreased. The data demonstrated hyaluronic acid and DS35 deacetylation and suggested a decrease of equatorial sulfates with infrared band at 840 cm-1 and an increase of axial sulfates with band at 860 cm-1 in DS28 and DS35 of the 75 +/- 5-year-old set. Equatorial Equatorial sulfates...Continue Reading

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Citations

Dec 12, 2012·Glycoconjugate Journal·Wuxia ZhangShunchun Wang
Jul 24, 2010·Journal of Pharmaceutical Sciences·Nathalie MainreckYanusz Wegrowski
Jan 1, 1991·Analytical Biochemistry·M O Longas, K O Breitweiser
Dec 31, 1992·Carbohydrate Research·M O Longas, H G Garg
Aug 6, 2014·Glycobiology·Wuxia ZhangJinyou Duan
Feb 20, 2018·Journal of Cell Communication and Signaling·Megan A ColeGary J Fisher
Dec 9, 2016·Glycoconjugate Journal·Hossam Taha MohamedStéphane Brézillon
Sep 16, 2019·Carbohydrate Polymers·Jakub SedláčekVladimír Velebný
Sep 17, 2020·Carbohydrate Polymers·Jakub SedláčekVladimír Velebný
Dec 30, 1999·Carbohydrate Research·M O LongasJ A Griep
Mar 21, 1993·Biochimica Et Biophysica Acta·M O LongasK O Breitweiser

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