Chemical analysis and screening as anticancer agent of anthocyanin-rich extract from Uva Caimarona ( Pourouma cecropiifolia Mart.) fruit

Journal of Agricultural and Food Chemistry
Juliana BarriosCoralia Osorio

Abstract

The anthocyanin-rich extract (ARE) of the fruit from Pourouma cecropiifolia , a tropical plant native to the Amazon region, showed moderate cytotoxicity toward different cancer cell lines when evaluated by MTT assays. This extract was fractionated using Sephadex LH-20 chromatography to obtain three fractions (F1-F3), the composition of which was analyzed by HPLC-PDA and LC-ESI/MS. F1 was composed primarily of the monomeric anthocyanins delphinidin-3-O-beta-glucopyranoside, cyanidin-3-O-beta-glucopyranoside, and cyanidin-3-O-(6''-malonyl)glucopyranoside. F2 contained the isomeric flavonols quercetin 3-O-alpha-rhamnopyranosyl-(1-->6)-beta-galactopyranoside and quercetin 3-O-alpha-rhamnopyranosyl-(1-->6)-beta-glucopyranoside, the structures of which were confirmed by (1)H and (13)C NMR. F3 contained polymeric pigments, which were analyzed using tandem ESI/MS with an ion trap-TOF. The structures of two proanthocyanidin and two flavanol-anthocyanin condensed pigments were suggested on the basis of their MS(n) fragmentation patterns. After cell viability assays were performed, only fraction F3 showed a cell growth-inhibitory effect similar to the one found for ARE. F3 significantly reduced the viability of HEp-2 larynx, MKN-45 gastri...Continue Reading

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Citations

Jan 17, 2012·Journal of Agricultural and Food Chemistry·Liliana SantacruzCoralia Osorio
Jan 1, 2016·Journal of Chromatography. a·André de VilliersHarald Pasch
Jul 21, 2015·Critical Reviews in Food Science and Nutrition·Daotong LiFang Chen
Apr 18, 2018·Natural Product Research·Ahmed R HassanSøren Brøgger Christensen
Jun 22, 2018·ChemMedChem·Srinivasa Reddy BonamVijayapandi Pandy
Jan 20, 2011·Journal of Agricultural and Food Chemistry·Katherine JaramilloCoralia Osorio
Jul 25, 2019·Journal of Agricultural and Food Chemistry·Francisco Tomas-Barberán, Coralia Osorio

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