PMID: 8584206Aug 11, 1995Paper

Chemical analysis of neurotransmitter candidates in clonal cell lines from Drosophila central nervous system, II: Neuropeptides and amino acids

Neuroscience Letters
K Ui-TeiY Miyata

Abstract

In a previous study, we have found acetylcholine and/or L-DOPA in 10 colonial clones from one cell line of Drosophila larval central nervous system (CNS). In this study, to characterize clonal neuronal phenotypes further, we have examined three neuropeptides and 19 amino acids using HPLC system. Substance P and proctolin were found in seven and eight out of ten clones, respectively. On the other hand, somatostatin was expressed in all ten clones. GABA and taurine were not detected in any clones. Glutamate, which is an excitatory transmitter in Drosophila, was found in all the clones, although its content was different seven times among them. Glycine, which is not known as a transmitter in Drosophila, was found to be unevenly expressed among them. Therefore, the conspicuous expression of peptides or amino acids in some clones suggests that the substances have a special role in Drosophila CNS.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A UltschH Betz
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H Ffrench-ConstantR T Roush
Jan 22, 1990·Brain Research·D R NässelL Grimelius
Jan 1, 1970·Annual Review of Physiology·C Hebb
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L Y Jan, Y N Jan
Apr 1, 1993·Physiological Reviews·M Otsuka, K Yoshioka
Apr 1, 1994·In Vitro Cellular & Developmental Biology. Animal·K UiT Miyake
Dec 1, 1993·Trends in Pharmacological Sciences·H BetzB Schmitt

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Citations

Jun 7, 2008·Cellular and Molecular Life Sciences : CMLS·A Delwig, M D Rand
Jan 26, 1996·Neuroscience Letters·K Ui-TeiY Miyata
Jan 8, 2010·The Journal of Biological Chemistry·Anna GrygorukDavid E Krantz
Mar 28, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew D RandJeffrey Bond
May 31, 2001·Genome Research·R S Hewes, P H Taghert
Jun 8, 2006·Neurotoxicology·Christin Bland, Matthew D Rand
Jan 19, 2018·Journal of Leukocyte Biology·Sergei SpitsinSteven D Douglas
Nov 6, 2015·Journal of Neurophysiology·Kiel G OrmerodA Joffre Mercier
Oct 12, 2018·Journal of Neurogenetics·Kiel G OrmerodA Joffre Mercier

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