Chemical and biological analyses of the essential oils and main constituents of Piper species.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Dominique F Moura do CarmoJefferson Rocha de Andrade Silva

Abstract

The essential oils obtained from leaves of Piper duckei and Piper demeraranum by hydrodistillation were analyzed by gas chromatography-mass spectrometry. The main constituents found in P. demeraranum oil were limonene (19.3%) and β-elemene (33.1%) and in P. duckei oil the major components found were germacrene D (14.7%) and trans-caryophyllene (27.1%). P. demeraranum and P. duckei oils exhibited biological activity, with IC(50) values between 15 to 76 μg mL(-1) against two Leishmania species, P. duckei oil being the most active. The cytotoxicity of the essential oils on mice peritoneal macrophage cells was insignificant, compared with the toxicity of pentamidine. The main mono- and sesquiterpene, limonene (IC(50) = 278 μM) and caryophyllene (IC(50) = 96 μM), were tested against the strains of Leishmania amazonensis, and the IC(50) values of these compounds were lower than those found for the essential oils of the Piper species. The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs.

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Citations

Apr 14, 2015·Nutrients·Potchanapond GraidistYaowapa Sukpondma
Dec 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karine Zanoli BernuciDiógenes Aparício Garcia Cortez
Dec 15, 2017·International Journal of Molecular Sciences·Joyce Kelly da SilvaWilliam N Setzer
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lianet MonzoteWilliam N Setzer
Dec 1, 2017·Pharmaceutical Biology·Lauriane Serpa Silva BosquiroliCarla Cardozo Pinto de Arruda
Jun 1, 2018·BioMed Research International·Igor A RodriguesAna Claudia F Amaral
Jul 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariana Margatto RottiniKátia da Silva Calabrese
Aug 4, 2020·Parasitology·Célia Eliane de Lara da SilvaMaria Valdrinez Campana Lonardoni
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiWilliam N Setzer
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lianet MonzoteWilliam N Setzer
Dec 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karine Zanoli BernuciDiógenes Aparício Garcia Cortez
Feb 1, 2020·Experimental Parasitology·Caroline Gomes MacêdoKelly Christina Ferreira Castro
Jul 11, 2021·Parasitology Research·Juliana Figueiredo PeixotoLuiz Filipe Gonçalves-Oliveira

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