PMID: 6169843Sep 1, 1981Paper

Chemical and Immunological characterization of the major structural protein (p28) of MMC-1, a rhesus monkey endogenous type C virus: homology with the major structural protein of avian reticuloendotheliosis virus

Journal of Virology
S OroszlanR V Gilden

Abstract

The major core protein (p28) of MMC-1, an endogenous type C virus of the rhesus monkey (Macaca mulatta), was purified and subjected to structural and immunological analyses. The NH2-terminal amino acid sequence of MMC-1 p28 showed extensive homology to the sequences of the major structural proteins (p30) of known mammalian type C viruses. Similarly, interspecies antigenic determinants shared by all the above viral proteins were detected in MMC-1 p28. Competition radioimmunoassays together with the results of statistical analysis of the primary structure data provided evidence that MMC-1 p28 is not more closely related to primate type C viruses of the Papio genus than to those isolated from rodents, cats, or New World monkeys. MMC-1 p28 was found to be closely related structurally to the p30 protein of the avian reticuloendotheliosis virus (REV-A), a horizontally transmitted type C virus of putative mammalian origin. In addition, MMC-1 p28 and REV-A p30 shared a specific subset of antigenic determinants not present in any of the other avian or mammalian type C viruses studied. These findings suggest that MMC-1 and REV may have a common evolutionary origin.

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S OroszlanR V Gilden
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S A Sherwin, G J Todaro
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·S OroszlanR V Gilden
Nov 1, 1974·Journal of Virology·C Y Kang, H M Temin
Feb 9, 1972·Nature: New Biology·T G KawakamiR V Gilden
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M BarbacidS A Aaronson
Jan 1, 1980·Journal of Virology·S Simek, N R Rice
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

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Citations

Dec 19, 2014·Avian Diseases·Karel A Schat, Hollis N Erb
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W S RobinsonP L Marion
May 1, 1983·Journal of Virology·A M Schultz, S Oroszlan

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