PMID: 6406830Jan 1, 1983Paper

Chemical and immunological properties of B. anthracis arginase and its metabolic involvement

Molecular and Cellular Biochemistry
E Soru

Abstract

An arginase isolated from a capsulated Bacillus anthracis strain was highly purified and crystallized. The chemical and immunological characteristics of this enzyme re described. Some very important properties differ from those of another bacterial arginase, i.e. Staphylococcus aureus arginase, described in a previous paper (Soru et al. (2)). The two arginases have different crystallization forms, different molecular weight, Km, thermostability, Arrhenius activation energy. They have another N-terminal group and are immunologically strictly specific. These differences point to distinct proteins. The fact that two arginases of different origin are structurally non-identical suggests that they may be involved in different metabolic processes. Staphylococcal arginase was shown to participate in a complete ureogenetic cycle, for it also possesses the other enzymes of the cycle (Soru et al. (2)). Except arginase, no other enzyme of this cycle was identified in the capsulated B. anthracis strain. Arginase may be involved in another metabolic pathway, one that is important for the strain, such as the synthesis of glutamic acid, since the capsular material of the strain is a polymer gamma-linked polyglutamic acid, mainly configuration ...Continue Reading

Citations

Sep 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·N CarvajalM Salas
May 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C P JenkinsonS D Cederbaum
Mar 23, 2006·Infection and Immunity·Kimberly W RainesGerald M Rosen
Dec 22, 1998·Biochimica Et Biophysica Acta·G L MendzR L Ferrero
Apr 29, 1991·Biochimica Et Biophysica Acta·M L PatchettH W Morgan
Nov 7, 2015·Microbiology Spectrum·Joel A BozueChristopher K Cote
Jun 24, 2021·FEMS Microbiology Reviews·Victor M HernándezMichael F Dunn

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