Feb 8, 2020

Chemical and Light Inducible Epigenome Editing

International Journal of Molecular Sciences
Weiye ZhaoFu-Sen Liang

Abstract

The epigenome defines the unique gene expression patterns and resulting cellular behaviors in different cell types. Epigenome dysregulation has been directly linked to various human diseases. Epigenome editing enabling genome locus-specific targeting of epigenome modifiers to directly alter specific local epigenome modifications offers a revolutionary tool for mechanistic studies in epigenome regulation as well as the development of novel epigenome therapies. Inducible and reversible epigenome editing provides unique temporal control critical for understanding the dynamics and kinetics of epigenome regulation. This review summarizes the progress in the development of spatiotemporal-specific tools using small molecules or light as inducers to achieve the conditional control of epigenome editing and their applications in epigenetic research.

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Mentioned in this Paper

Research
Gene Editing
Study
Regulation of Biological Process
Small Molecule
Genome, Bacterial
Genome
Gene Expression
Spatio-Temporal Analysis
Inhibition of Biological Process

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