Chemical and mechanical nerve root insults induce differential behavioral sensitivity and glial activation that are enhanced in combination

Brain Research
Sarah M Rothman, Beth A Winkelstein

Abstract

Both chemical irritation and mechanical compression affect radicular pain from disc herniation. However, relative effects of these insults on pain symptoms are unclear. This study investigated chemical and mechanical contributions for painful cervical nerve root injury. Accordingly, the C7 nerve root separately underwent chromic gut exposure, 10gf compression, or their combination. Mechanical allodynia was assessed, and glial reactivity in the C7 spinal cord tissue was assayed at days 1 and 7 by immunohistochemistry using GFAP and OX-42 as markers of astrocytes and microglia, respectively. Both chromic gut irritation and 10gf compression produced ipsilateral increases in allodynia over sham (p<0.048); combining the two insults significantly (p<0.027) increased ipsilateral allodynia compared to either insult alone. Behavioral hypersensitivity was also produced in the contralateral forepaw for all injuries, but only the combined insult was significantly increased over sham (p<0.031). Astrocytic activation was significantly increased over normal (p<0.001) in the ipsilateral dorsal horn at 1 day after either compression or the combined injury. By day 7, GFAP-reactivity was further increased for the combined injury compared to day 1...Continue Reading

References

Jun 1, 1988·British Journal of Rheumatology·P S Helliwell
Aug 15, 1995·Spine·J S Saal
Mar 15, 1995·Spine·K OlmarkerB Rydevik
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Dec 15, 1996·Spine·G B Andersson, J N Weinstein
Jul 15, 1997·Spine·D D OhnmeissJ Ekholm
Sep 3, 1998·Seminars in Arthritis and Rheumatism·P GoupilleA J Freemont
Dec 10, 1999·Spine·G A LoupasisG Hartofilakidis
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mamoru KawakamiKoichi Kuribayashi
Oct 3, 2003·Trends in Neurosciences·Eric A Newman
Dec 5, 2003·Nature Reviews. Drug Discovery·Linda R Watkins, Steven F Maier
Aug 4, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Srinivasu KallakuriJohn M Cavanaugh
Nov 10, 2004·Spine·Michael CornefjordHelena Brisby
Jan 26, 2005·Trends in Neurosciences·Makoto TsudaMichael W Salter
Mar 10, 2005·Experimental Neurology·Stephen B McMahonFabien Marchand
Mar 28, 2006·Pain·Joyce A De LeoMichael L LaCroix-Fralish
Apr 12, 2006·Journal of Neurochemistry·Minoru NaritaTsutomu Suzuki

❮ Previous
Next ❯

Citations

Mar 24, 2010·Annals of Biomedical Engineering·Sarah M Rothman, Beth A Winkelstein
Jun 1, 2012·Journal of Biomedical Science·Tsung-Chieh ChenBai-Chuang Shyu
Aug 1, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Antonio GattiAlessandro Fabrizio Sabato
Oct 14, 2008·The Journal of Pain : Official Journal of the American Pain Society·Sarah M RothmanBeth A Winkelstein
Feb 22, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nadine M DunkBeth A Winkelstein
Aug 26, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Nathan D CrosbyBeth A Winkelstein
Jan 7, 2017·Journal of Neurosurgery. Spine·Jenell R Smith, Beth A Winkelstein
Apr 27, 2011·Journal of Korean Neurosurgical Society·Dong Charn ChoChoong Hyun Kim
Feb 7, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Julia C Quindlen-HotekBeth A Winkelstein
Jun 2, 2018·Clinics in Orthopedic Surgery·Arun-Kumar Kaliya-PerumalRaj-Prabhakar Sumathi-Edirolimanian
May 24, 2019·Cells·Luciana Politti CartarozziAlexandre Leite Rodrigues de Oliveira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.