Chemical and structural biology of protein lysine deacetylases

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Minoru YoshidaAkihiro Ito

Abstract

Histone acetylation is a reversible posttranslational modification that plays a fundamental role in regulating eukaryotic gene expression and chromatin structure/function. Key enzymes for removing acetyl groups from histones are metal (zinc)-dependent and NAD(+)-dependent histone deacetylases (HDACs). The molecular function of HDACs have been extensively characterized by various approaches including chemical, molecular, and structural biology, which demonstrated that HDACs regulate cell proliferation, differentiation, and metabolic homeostasis, and that their alterations are deeply involved in various human disorders including cancer. Notably, drug discovery efforts have achieved success in developing HDAC-targeting therapeutics for treatment of several cancers. However, recent advancements in proteomics technology have revealed much broader aspects of HDACs beyond gene expression control. Not only histones but also a large number of cellular proteins are subject to acetylation by histone acetyltransferases (HATs) and deacetylation by HDACs. Furthermore, some of their structures can flexibly accept and hydrolyze other acyl groups on protein lysine residues. This review mainly focuses on structural aspects of HDAC enzymatic acti...Continue Reading

References

Jan 1, 1976·The Journal of Antibiotics·N TsujiK Koizumi
May 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M YoshidaT Beppu
Oct 10, 1996·Nature·Z F KanyoD W Christianson
Jun 20, 1998·Experimental Cell Research·H NakajimaS Horinouchi
Sep 23, 1998·Genes & Development·K SakaguchiE Appella
Aug 3, 2000·Journal of the National Cancer Institute·P A MarksR A Rifkind
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B M Turner
Aug 11, 2001·Science·T Jenuwein, C D Allis
Oct 24, 2001·Cell·H VaziriR A Weinberg
May 25, 2002·Nature·Charlotte HubbertTso-Pang Yao
Nov 12, 2002·The EMBO Journal·Akihiro ItoTso-Pang Yao
Dec 18, 2002·The EMBO Journal·Akihisa MatsuyamaMinoru Yoshida
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Nov 18, 2005·Gene·Michele A GlozakEdward Seto
Jan 28, 2006·Cell·Raul MostoslavskyFrederick W Alt
Mar 29, 2006·Journal of Biotechnology·Christian HildmannAndreas Schwienhorst
May 2, 2006·Genes & Development·Alejandro VaqueroDanny Reinberg

❮ Previous
Next ❯

Citations

Feb 13, 2019·Human Molecular Genetics·Frédéric AnglèsWilliam E Balch
May 5, 2018·Annual Review of Biochemistry·Tilman Schneider-Poetsch, Minoru Yoshida
Feb 6, 2020·Expert Opinion on Therapeutic Patents·Chunlong ZhaoYingjie Zhang
Aug 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tasha B Toro, Terry J Watt
Oct 26, 2018·Frontiers in Genetics·Vera Miranda-GonçalvesCarmen Jerónimo
Apr 25, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Norio KudoMinoru Yoshida
Apr 25, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Ganesan
Nov 23, 2017·Frontiers in Endocrinology·Nabil RabhiJean-Sébastien Annicotte
Nov 19, 2019·Advanced Biomedical Research·Masumeh Sanaei, Fraidoon Kavoosi
Oct 9, 2020·International Journal of Molecular Sciences·Antonella SferraEnrico Bertini
Sep 24, 2020·Plant & Cell Physiology·Kaori SakoMotoaki Seki
Nov 5, 2017·Analytical Biochemistry·Tasha B ToroTerry J Watt
Jul 2, 2020·Journal of Medicinal Chemistry·Terence C S HoA Ganesan
Apr 13, 2021·Journal of Biomedical Science·Kunal Nepali, Jing-Ping Liou
May 11, 2021·British Journal of Clinical Pharmacology·Andrey D BondarevHelgi B Schiöth
May 17, 2021·Neurochemistry International·Jean Lud Cadet, Subramaniam Jayanthi
Aug 26, 2021·Biological Chemistry·Anna-Theresa BlaslMichael Lammers
Oct 16, 2021·Current Topics in Medicinal Chemistry·Daniel Alencar RodriguesTríona Ní Chonghaile

❮ Previous
Next ❯

Methods Mentioned

BETA
Histone acetylation
acetylation
deacylation
Knockout
X-ray
ubiquitination
acylation

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.