Chemical and toxicological characteristics of conventional and low-TSNA moist snuff tobacco products

Toxicology Letters
Min-Ae SongPeter G Shields

Abstract

Use of smokeless tobacco products (STPs) is associated with oral cavity cancer and other health risks. Comprehensive analysis for chemical composition and toxicity is needed to compare conventional and newer STPs with lower tobacco-specific nitrosamines (TSNAs) yields. Seven conventional and 12 low-TSNA moist snuff products purchased in the U.S., Sweden, and South Africa were analyzed for 18 chemical constituents (International Agency for Research on Cancer classified carcinogens), pH, nicotine, and free nicotine. Chemicals were compared in each product using Wilcoxon rank-sum test and principle component analysis (PCA). Conventional compared to low-TSNA moist snuff products had higher ammonia, benzo[a]pyrene, cadmium, nickel, nicotine, nitrate, and TSNAs and had lower arsenic in dry weight content and per mg nicotine. Lead and chromium were significantly higher in low-TSNA moist snuff products. PCA showed a clear difference for constituents between conventional and low-TSNA moist snuff products. Differences among products were reduced when considered on a per mg nicotine basis. As one way to contextualize differences in constituent levels, probabilistic lifetime cancer risk was estimated for chemicals included in The Universit...Continue Reading

References

Jan 1, 1991·Critical Reviews in Toxicology·D HoffmannS S Hecht
Dec 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B G Osterdahl, S A Slorach
Apr 3, 1998·Advances in Dental Research·D Hoffmann, M V Djordjevic
Apr 30, 1998·Scandinavian Journal of Work, Environment & Health·L Teppo
May 8, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E F Domino
Jul 15, 1998·International Journal of Cancer. Journal International Du Cancer·E B SchildtA Magnuson
Jul 28, 1999·The Journal of the American Dental Association·G C MartinG D Houston
Sep 2, 1999·International Journal of Cancer. Journal International Du Cancer·W YeO Nyrén
Dec 9, 2003·Tobacco Control·J FouldsK Fagerström
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Ana Navas-AcienJonathan Samet
Oct 8, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Brad Rodu, Christer Jansson
Aug 9, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephen S HechtDorothy K Hatsukami
Dec 6, 2007·American Journal of Preventive Medicine·Dorothy K HatsukamiStephen S Hecht
Feb 29, 2008·Harm Reduction Journal·Jonathan Foulds, Helena Furberg
Apr 24, 2008·Journal of Analytical Toxicology·R S PappasD L Ashley
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Irina StepanovStephen S Hecht
Nov 22, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Irina StepanovStephen S Hecht
Jan 13, 2009·Regulatory Toxicology and Pharmacology : RTP·W S RickertJ H Lauterbach
Oct 29, 2009·Chemical Research in Toxicology·Irina StepanovStephen S Hecht
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michael D JohnsonPeter G Shields
Sep 28, 2010·Journal of the National Cancer Institute·Renee Twombly
May 18, 2011·Harm Reduction Journal·Lars E RutqvistInger Wahlberg
Sep 19, 2012·International Journal of Cancer. Journal International Du Cancer·Jiachen ZhouKarl T Kelsey
Sep 25, 2012·Regulatory Toxicology and Pharmacology : RTP·M F BorgerdingJ E Swauger
Nov 3, 2012·Tobacco Control·Cristine D DelnevoPamela M Ling
Mar 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tameka S LawlerClifford H Watson
Oct 2, 2013·Indian Journal of Pharmaceutical Sciences·V PrabhakarB Ranganathan
May 17, 2014·Cancers·Jiaping XueSeyha Seng

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Citations

Jul 15, 2017·Journal of Periodontology·Thomas E LallierErin Maturin
Oct 24, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Micah L BermanDorothy K Hatsukami
May 18, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Walter J JessenG L Prasad
Dec 6, 2017·PloS One·Christina Herland FløtreAnne-Lise Bjørke-Monsen
Feb 7, 2019·International Journal of Epidemiology·Sofia CarlssonTomas Andersson
Oct 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bishop EGaca M
Feb 18, 2021·Nutrition and Cancer·Zoia RazumovaMiriam Mints
Jul 3, 2020·Toxicology Reports·M J OldhamJ A Strickland

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