Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

Chemical Communications : Chem Comm
Qingshuo MengYaping Li

Abstract

We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against several cancer cell lines. Experimental and simulation results reveal that the annihilation abates with increasing distance between the PS and drugs via confining the PS and drugs into separated vehicles. As a result, antagonism can be switched to synergism in treating both drug sensitive and resistant cancer cells.

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Citations

Mar 24, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Susan Callaghan, Mathias O Senge
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peiwei GongZhe Liu

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
Fluorescence
nuclear magnetic resonance
NMR

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