PMID: 6399165Jan 1, 1983Paper

Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype

Toxicologic Pathology
J K ReddyN D Lalwani

Abstract

Chemical carcinogens can be classified into two categories (i.e. mutagenic and non-mutagenic) on the basis of positive or negative evidence of DNA damage, mutagenicity or chromosomal aberrations in short-term test systems. Evidence indicates that carcinogenic peroxisome proliferators are negative in short-term test systems. This paper outlines approaches which may be useful in identifying a chemical carcinogen without mutagenic activity. It is conceivable that an alteration in DNA, if essential for initiation of neoplasia, may be mediated indirectly by the biological effects of nonmutagenic carcinogens.

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Citations

Apr 5, 2001·Journal of Applied Toxicology : JAT·J Kato-WeinsteinR J Bull
Jan 1, 1994·Teratogenesis, Carcinogenesis, and Mutagenesis·K T KitchinA P Kulkarni
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·W Lijinsky, R M Kovatch
Feb 14, 2002·Biochemical Pharmacology·Arnaud BianchiMichel Dauça
May 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J T Hong, H P Glauert
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W E FahlJ K Reddy
Jun 1, 1991·Environmental Health Perspectives·M S Rao, J K Reddy
Dec 1, 1993·Environmental Health Perspectives·J A Styles
Feb 8, 2011·Toxicology and Applied Pharmacology·James E KlaunigShaoyu Zhou
May 4, 2004·Mutation Research·Paul D CornwellRoger G Ulrich
Dec 16, 2010·Regulatory Toxicology and Pharmacology : RTP·Antonia OrsiGermano Oberto
Dec 19, 2009·Toxicologic Pathology·James E KlaunigBarbara A Hocevar
Dec 27, 1996·Annals of the New York Academy of Sciences·V NilakantanH P Glauert

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