Chemical castration induced by adjuvant cyclophosphamide, methotrexate, and fluorouracil chemotherapy causes rapid bone loss that is reduced by clodronate: a randomized study in premenopausal breast cancer patients

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
T SaartoI Elomaa

Abstract

In the majority of premenopausal breast cancer patients, an adjuvant chemotherapy-induced early menopause occurs, which is known to be a strong predictor of osteoporosis. We present data on the effect of adjuvant cyclophosphamide, methotrexate, and fluorouracil (CMF) therapy on bone mineral density (BMD) and the efficacy of clodronate on the prevention of bone loss in 148 premenopausal breast cancer patients without skeletal metastases. Patients were randomized to receive oral clodronate 1,600 mg/d or to a control group. In addition, patients were treated with six cycles of CMF therapy. BMD of the lumbar spine and femoral neck was measured by dual-energy x-ray absorptiometry (DEXA) before therapy and at 1 and 2 years. Changes in the BMD of lumbar spine and femoral neck were -5.9% and -2.0% without clodronate and -2.2% and +0.9% with clodronate at 2 years (P = .0005 and .017, respectively). Patients who developed amenorrhea after chemotherapy had a rapid bone loss, which was significantly reduced by clodronate. In controls, bone loss was 9.5% in the lumbar spine and 4.6% in the femoral neck, while in the clodronate group, bone loss was 5.9% and 0.4%, respectively, at 2 years. Patients with preserved menstruation had only margina...Continue Reading

Citations

Oct 12, 2001·Current Oncology Reports·J R Gralow
Jan 28, 2003·Cancer·Timothy A Plunkett, Robert D Rubens
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce E HillnerUNKNOWN American Society of Clinical Oncology
Mar 17, 2005·Breast Cancer Research and Treatment·Charles L ShapiroStan Lemeshow
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Yi-Hsiung LinMei-Chun Hsiao
May 18, 2005·Oncology Nursing Forum·Cathy Maxwell, Pamela Hallquist Viale
Apr 2, 2005·Breast Cancer Research and Treatment·S LeppäI Elomaa
Feb 18, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Laura Boehnke Michaud, Susan Goodin
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F X GnantUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Jan 9, 2007·The Journal of Clinical Endocrinology and Metabolism·Richard Eastell
Apr 24, 2008·Current Osteoporosis Reports·Mimi I HuCamilo Jimenez
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn L HershmanElizabeth Shane
May 6, 2008·Cancer Nursing·Nancy L WaltmanTimothy E Moore
Feb 28, 2009·Women's Health·Martin Pecherstorfer
Feb 15, 2011·Journal of Aging Research·Erik D Hanson, Ben F Hurley
Oct 16, 2010·Annals of the New York Academy of Sciences·Robert Coleman
Sep 6, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T SaartoC Blomqvist
Aug 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Larissa A Korde, Julie R Gralow
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam B LustbergCharles L Shapiro
Mar 20, 2013·Nature Reviews. Rheumatology·Robert E ColemanJanet E Brown
Oct 23, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R RizzoliUNKNOWN International Osteoporosis Foundation Committee of Scientific Advisors Working Group on Cancer-Induced Bone Disease
Dec 26, 2018·Current Breast Cancer Reports·Arielle HeekeFilipa Lynce
Aug 25, 2020·Expert Opinion on Biological Therapy·Emanuela Dell'AquilaDaniele Santini
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T SaartoI Elomaa
May 20, 1998·Journal of the National Cancer Institute·T J PowlesJ Kanis
Dec 15, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·R E Coleman
Mar 31, 1999·British Journal of Cancer·J A KanisT Spector
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E HillnerD G Pfister
Dec 21, 2004·Breast Cancer Research and Treatment·C CrandallG A Greendale
May 10, 2005·Expert Review of Anticancer Therapy·Robert KrempienJürgen Debus
May 10, 2008·Acta Oncologica·Nina H BjarnasonPeter Vestergaard
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A SverrisdóttirL E Rutqvist
Apr 23, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan L GreenspanVictor G Vogel
Nov 5, 2005·Oncology Nursing Forum·Catherine JansenJoel Kramer
Sep 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tiina SaartoInkeri Elomaa
Oct 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred SaadKathleen I Pritchard
Jan 31, 2009·The Oncologist·Tim Van den WyngaertJan B Vermorken
Jan 22, 2011·Calcified Tissue International·Peter VestergaardPeer Christiansen
Oct 19, 2006·The Journal of Clinical Endocrinology and Metabolism·Susan L GreenspanVictor G Vogel
Jul 26, 2011·Current Opinion in Supportive and Palliative Care·C Wilson, R E Coleman
Apr 10, 2010·Expert Opinion on Emerging Drugs·Francesco BertoldoStefania Boldini
Jun 11, 2010·American Journal of Clinical Oncology·Allan Lipton
Aug 16, 2016·Asia-Pacific Journal of Clinical Oncology·Suk Woo LeeDong Choon Park

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