Chemical characterisation and toxicity assessment in vitro and in vivo of the hydroethanolic extract of Terminalia argentea Mart. leaves

Journal of Ethnopharmacology
Angela Márcia Selhorst E Silva BeserraDomingos Tabajara de Oliveira Martins

Abstract

Terminalia argentea Mart. (Combretaceae), known mainly as "capitão", is a native tree, not endemic, that occurs in the Amazon, Caatinga, Cerrado and Atlantic Forest in Brazil. Leaf infusion is popularly mentioned by riverine communities that inhabit the microregion of Northern Araguaia (Mato Grosso, Brazil) for the treatment of gastric ulcer, bronchitis and haemorrhage. Considering the wide medicinal use, lack of studies that evaluate the safety of use and the scarcity of phytochemical studies of T. argentea leaves, this work was carried out with the objective of evaluating the toxicity of the hydroethanolic extract of the leaves of T. argentea Mart. (HETa) in experimental models in vivo and in vitro, as well as to advance the phytochemical analysis of HETa. HETa was prepared by macerating the leaf powder in hydroethanolic solution. Phytochemical characterisation was carried out by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) and mass spectrometry through direct flow infusion coupled with electrospray ionization and ion-trap analyzer (DFI-ESI-IT-MS analyses) The contents of phenols, flavonoids and phytosterols were analysed by colorimetric methods. Cytotoxicity was assessed by the Alamar blue a...Continue Reading

References

May 26, 1997·Journal of Immunological Methods·G R NakayamaZ Parandoosh
Oct 13, 2000·Regulatory Toxicology and Pharmacology : RTP·H OlsonA Heller
Mar 14, 2002·Toxicologic Pathology·Richard W LewisFrancis Carpanini
Feb 5, 2003·The American Journal of Medicine·Penny M Kris-EthertonTerry D Etherton
Sep 2, 2003·Mutation Research·Magdalena LabieniecGiancarlo Falcioni
May 17, 2005·Journal of Ethnopharmacology·P MasokoJ N Eloff
May 23, 2007·Biological Chemistry·Olaf BoehmKai Zacharowski
Jun 5, 2007·Nature Protocols·Michael Fenech
Apr 25, 2008·Current Protocols in Immunology·W Strober
Jun 17, 2008·Mutation Research·D UteschT C Lines
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lih-Geeng ChenChing-Chiung Wang
Apr 16, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Francisco José MininelLourdes Campaner Dos Santos
Sep 1, 2011·Phytotherapy Research : PTR·Gustavo R M BarcelosFernando Barbosa
Jan 28, 2015·Pharmaceutical Biology·Murali Mohan ReddyBright Starling Emerald
Apr 25, 2015·Journal of the Science of Food and Agriculture·Pravin Digambar SawaleGirdhari Ramdas Patil
Jun 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rodrigo Pinheiro AraldiRita de Cassia Stocco
Jul 25, 2015·Biochemical Pharmacology·Antonio J León-GonzálezValérie B Schini-Kerth
Dec 15, 2015·Frontiers in Cardiovascular Medicine·Carlo M BarbagalloMaurizio R Averna
Feb 19, 2016·Phytotherapy Research : PTR·Angelo A IzzoElizabeth M Williamson
Jul 2, 2016·Pharmacognosy Research·B E Ravi ShankaraBhadrapura Lakkappa Dhananjaya
Mar 21, 2017·Oxidative Medicine and Cellular Longevity·Lada ŽivkovićBiljana Spremo-Potparević
May 10, 2017·Journal of Ethnopharmacology·Reginaldo Vicente RibeiroDomingos Tabajara de Oliveira Martins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.