PMID: 6104985Jul 10, 1980Paper

Chemical characterization and substrate specificity of rabbit liver aryl sulfatase A

Biochimica Et Biophysica Acta
A Waheed, R L Van Etten

Abstract

Rabbit liver aryl sulfatase A (aryl-sulfate sulfohydrolase, EC 3.1.6.1) is a glycoprotein containing 4.6% carbohydrate in the form of 25 residues of mannose, seven residues of N-acetylglucosamine, and three residues of sialic acid per enzyme monomer of molecular weight 140 000. Each monomer consists of two equivalent polypeptide chains. The protein has a relatively high content of proline, glycine and leucine, and the amino acid composition of rabbit liver aryl sulfatase A is similar to that of other known liver sulfatases. Rabbit liver aryl sulfatase A catalyzes the hydrolysis of a wide variety of sulfate esters, although it appears possible that cerebroside sulfate is a physiological substrate for the enzyme because the Km is very low (0.06 mM). The turnover rate for hydrolysis of nitrocatechol sulfate or related synthetic substrates is much higher than the rate with most naturally occurring sulfate esters such as cereroside sulfate, steroid sulfates, L-tyrosine sulfate or glucose 6-sulfate. However, the turnover rate with ascorbate 2-sulfate is comparable to the rates measured using most synthetic substrates. These results are discussed in relationship to several previously described sulfatase enzymes which were claimed to h...Continue Reading

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Citations

Jan 1, 1981·The International Journal of Biochemistry·A A Farooqui, P N Srivastava
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A WaheedR L Van Etten
Jun 12, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Hongbin XuNongnuj Tanphaichitr
Aug 15, 1987·Analytical Biochemistry·A B Roy
Jun 1, 1994·Chemico-biological Interactions·K S PangM Chiba
Aug 1, 1980·Archives of Biochemistry and Biophysics·A Waheed, R L Van Etten
Apr 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·A WaheedK von Figura
Jun 25, 2002·Biology of Reproduction·Julierut TantibhedhyangkulNongnuj Tanphaichitr
Oct 1, 1985·International Journal of Peptide and Protein Research·A Waheed, R L Van Etten
Jun 4, 1982·Biochimica Et Biophysica Acta·A B Roy, J Turner
Sep 20, 1985·Biochimica Et Biophysica Acta·A Waheed, R L Van Etten

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