Chemical Characterization, Free Radical Scavenging, and Cellular Antioxidant and Anti-Inflammatory Properties of a Stilbenoid-Rich Root Extract of Vitis vinifera

Oxidative Medicine and Cellular Longevity
Tuba EsatbeyogluGerald Rimbach

Abstract

Dietary stilbenoids are receiving increasing attention due to their potential health benefits. However, most studies concerning the bioactivity of stilbenoids were conducted with pure compounds, for example, resveratrol. The aim of this study was to characterize a complex root extract of Vitis vinifera in terms of its free radical scavenging and cellular antioxidant and anti-inflammatory properties. HPLC-ESI-MS/MS analyses of the root extract of Vitis vinifera identified seven stilbenoids including two monomeric (resveratrol and piceatannol), two dimeric (trans-ɛ-viniferin and ampelopsin A), one trimeric (miyabenol C), and two tetrameric (r-2-viniferin = vitisin A and r-viniferin = vitisin B) compounds which may mediate its biological activity. Electron spin resonance and spin trapping experiments indicate that the root extract scavenged 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, galvinoxyl, and superoxide free radicals. On a cellular level it was observed that the root extract of Vitis vinifera protects against hydrogen peroxide-induced DNA damage and induces Nrf2 and its target genes heme oxygenase-1 and γ-glutamylcysteine synthetase. Furthermore, the root extract could induce the antiatherogenic hepatic enzyme paraoxonase 1 an...Continue Reading

References

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Citations

Mar 16, 2017·Journal of Agricultural and Food Chemistry·Julien GabastonJean-Michel Mérillon
Jan 8, 2020·Biomolecules·Haroon KhanEsra Küpeli Akkol
May 23, 2019·Frontiers in Nutrition·Colin E Champ, Anjali Kundu-Champ
Sep 1, 2017·Annals of the New York Academy of Sciences·J Luis Espinoza, Pleiades T Inaoka
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto RomeoDaniela Iannazzo

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Methods Mentioned

BETA
ESR
PCR
electron spin resonance
protein assay
Assay
transfection
Human

Software Mentioned

Primer3
PASW Statistics

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