PMID: 7027034Nov 1, 1981Paper

Chemical characterization of direct-acting airborne mutagens: the functional group

Mutation Research
R Talcott, W Harger

Abstract

Durham NC air was sampled, extracted, and bioassayed for mutagenic activity in Salmonella typhimurium TA98. Portions of the extracts were treated with sodium borohydride over copper (II) acetylacetonate to reduce any nitroaromatic substances to their corresponding amines. All of the reduced extracts were not directly mutagenic, but the 2 that were derived from cold-weather air samplings did contain substances that could be activated oxidatively. These "indirect-acting" mutagens were present in the same 2 reduced extracts that contained detectable concentrations of aromatic amines. These results suggest that a major portion of the total mutagenic activity in air-pollution particles is contributed by nitro-substituted compounds that are detectable as their corresponding amines. They also suggest that the atmospheric concentrations of these substances may be high in the colder months of Durham's year.

References

Apr 1, 1977·Mutation Research·H TokiwaY Ohnishi
Jan 1, 1978·Cancer Letters·W DehnenR Tomingas
Jan 1, 1978·Journal of Toxicology and Environmental Health·B CommonerA J Vithayathil
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Apr 1, 1975·Analytical Chemistry·B E Saltzman, J E Cuddeback
Oct 1, 1980·Mutation Research·R Talcott, W Harger

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Citations

Jul 1, 1985·The Science of the Total Environment·W K de RaatS A Kooijman
May 1, 1987·The Science of the Total Environment·W K De RaatF A De Meijere
Jan 1, 1986·Mutation Research·K C DonnellyS Safe
Jan 1, 1988·Journal of Toxicology and Environmental Health·K C DonnellyS Safe
Jan 1, 1983·Environmental Health Perspectives·T NielsenA Bjørseth
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Jan 1, 1984·Environmental Mutagenesis·W R HarrisD W Later

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