Chemical clearance in infants and children with Acid reflux in the physiologic range

Journal of Pediatric Gastroenterology and Nutrition
Frederick W WoodleyHayat Mousa

Abstract

We reported that chemical clearance (CC) of acid gastroesophageal reflux (AGER) is relatively prolonged in children with cystic fibrosis (CF). Disparity in CC values within our CF cohort sparked curiosity as to what CC looks like in infants and children with AGER in the physiologic range. The aim of the study was to assess CC in infants and children with normal AGER. Impedance-pH tracings from our database for infants (≤ 12 months) and children (>12 months-18 years) were manually scanned for 2-phase AGER episodes. Tracings were excluded for patients who had AGER Indices >3% (children) or >6% (infants), had positive GER-symptom associations, were on antireflux medications, had a fundoplication, or had impedance studies shorter than 18 hour. In addition to medians (25%-75% interquartile range), we calculated the 95th percentile for the CC duration and the fifth percentile for the CC rate. Two-phase AGER episodes were detected in 44 infants and 60 children. The median CC duration was 64.3 seconds (51.0-91.6 seconds) for infants and 37.5 seconds (27.7-52.4 seconds) for children. The median CC rate was 0.0622 pH units/second (PU/second) (0.0354-0.0946 PU/second) for infants and 0.0928 PU/second (0.0631-0.2057 PU/second) for children...Continue Reading

References

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Citations

Oct 14, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Frederick W WoodleyHayat Mousa
May 11, 2017·Frontiers in Pediatrics·Maheen Hassan, Hayat Mousa
Sep 11, 2018·Paediatric Drugs·Steven L Ciciora, Frederick W Woodley

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