Chemical components from the leaves of Ardisia insularis and their cytotoxic activity

Archives of Pharmacal Research
Nguyen Thi Hong VanSeung Hyun Kim

Abstract

One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3''-O-galloyl)-α-L-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3'-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves of Ardisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound 1 inhibited A-549, HT-29, and OVCAR cell lines with IC50 values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound 1 could be useful in the treatment of cancer disease.

References

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Oct 30, 2003·Journal of Agricultural and Food Chemistry·Alessandra BracaNunziatina De Tommasi
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Jun 16, 2009·Bioorganic & Medicinal Chemistry Letters·Yoshiyuki AiharaToshiyuki Kan
Mar 3, 2010·Archives of Pharmacal Research·Van Kiem PhanYoung Ho Kim
Feb 3, 2012·Archives of Pharmacal Research·Nguyen Xuan NhiemYoung Ho Kim
Feb 9, 2012·Planta medica·Li-Hua MuPing Liu
Sep 21, 2012·Natural Product Research·Li-Hua MuPing Liu

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