Chemical composition and antifungal activity of the essential oil of Thymbra capitata

Planta medica
L R SalgueiroJosé Martinez-de-Oliveira

Abstract

The composition and the antifungal activity of the essential oil of Thymbra capitata on Candida, Aspergillus and dermatophyte strains were studied. Twenty-two samples of the essential oils from the aerial parts of the plant were obtained by hydrodistillation and analysed by GC and GC-MS. All samples are of the carvacrol type, with a high content of carvacrol (60.0 - 65.8 %) and its biogenetic precursors, gamma-terpinene (8.2 - 9.5 %) and p-cymene (6.0 - 7.5 %). The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity against Candida (7 clinical isolates and 3 ATCC type strains), Aspergillus (5 clinical isolates, 2 CECT and 2 ATCC type strains) and 5 dermatophyte clinical strains. To clarify its mechanism of action on Candida strains, the inhibition of germ tube and a flow cytometry assay with propidium iodide (PI) were used. The oil exhibited antifungal activity for all the tested strains, particularly for dermatophytes, with MIC values ranging from 0.08 to 0.32 microL/mL. Regarding Candida, concentrations lower than the MIC values prevented germ tube formation. After a short incubation time the cells incorporated quickly PI, meaning that the fungicidal ...Continue Reading

Citations

Oct 25, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M ZuzarteL Salgueiro
Sep 28, 2007·Journal of Applied Microbiology·S SoyluS Kurt
May 16, 2006·Journal of Applied Microbiology·C CavaleiroL Salgueiro
Feb 16, 2011·Journal of Medical Microbiology·Mónica ZuzarteLígia Salgueiro
May 10, 2013·Journal of Medical Microbiology·Yuxin ChenYouwei Wang
Jan 21, 2015·Natural Product Research·Teresa TuttolomondoSalvatore La Bella
Nov 5, 2013·Journal of Ethnopharmacology·T A F EissaM P Gómez-Serranillos
Feb 9, 2012·Journal of Ethnopharmacology·A Palmeira-de-OliveiraA G Rodrigues
Nov 23, 2013·Critical Reviews in Food Science and Nutrition·Yi Xin SeowHyun-Gyun Yuk
Jun 28, 2016·Applied and Environmental Microbiology·Foteini KarampoulaFlorence Dubois-Brissonnet
Aug 22, 2009·Chemistry & Biodiversity·Monica ZuzarteLígia R Salgueiro
Jan 16, 2020·Biomolecules·Tomasz M Karpiński
Sep 29, 2006·Journal of Medical Microbiology·Eugénia PintoJosé Martinez-de-Oliveira
Oct 25, 2016·Mycopathologia·Graciliana LopesLígia Salgueiro
Jun 14, 2018·Frontiers in Microbiology·Nilce M Martinez-RossiAntonio Rossi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of the European Academy of Dermatology and Venereology : JEADV
C Pina-VazJosé Martinez-de-Oliveira
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
F BakkaliM Idaomar
© 2022 Meta ULC. All rights reserved