May 12, 2015

Chemical composition and disruption of quorum sensing signaling in geographically diverse United States propolis

Evidence-based Complementary and Alternative Medicine : ECAM
Michael A SavkaVassya Bankova

Abstract

Propolis or bee glue has been used for centuries for various purposes and is especially important in human health due to many of its biological and pharmacological properties. In this work we showed quorum sensing inhibitory (QSI) activity of ten geographically distinct propolis samples from the United States using the acyl-homoserine lactone- (AHL-) dependent Chromobacterium violaceum strain CV026. Based on GC-MS chemical profiling the propolis samples can be classified into several groups that are as follows: (1) rich in cinnamic acid derivatives, (2) rich in flavonoids, and (3) rich in triterpenes. An in-depth analysis of the propolis from North Carolina led to the isolation and identification of a triterpenic acid that was recently isolated from Hondurian propolis (Central America) and ethyl ether of p-coumaric alcohol not previously identified in bee propolis. QSI activity was also observed in the second group US propolis samples which contained the flavonoid pinocembrin in addition to other flavonoid compounds. The discovery of compounds that are involved in QSI activity has the potential to facilitate studies that may lead to the development of antivirulence therapies that can be complementary and/or alternative treatmen...Continue Reading

  • References33
  • Citations2

References

  • References33
  • Citations2

Mentioned in this Paper

Derivatives
Isolation Aspects
Gas Chromatography-Mass Spectrometry
3-hydroxyflavone
Ethers
Cell-cell Signaling Involved in Quorum Sensing
Anesthetic ether
Coumaric Acids
Flavonoids
Propolis

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