Chemical Composition, Antibacterial, Schistosomicidal, and Cytotoxic Activities of the Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae)

Chemistry & Biodiversity
Marina H SoaresAntônio E M Crotti

Abstract

We have investigated the chemical composition and the antibacterial activity of the essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) (DA-EO) against a representative panel of cariogenic bacteria. We have also assessed the in vitro schistosomicidal effects of DA-EO on Schistosoma mansoni and its cytotoxicity to GM07492-A cells in vitro. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS) revealed that the monoterpenes cis-piperitone oxide (35.2%), p-cymene (14.5%), isoascaridole (14.1%), and α-terpinene (11.6%) were identified by as the major constituents of DA-EO. DA-EO displayed weak activity against Streptococcus sobrinus and Enterococcus faecalis (minimum inhibitory concentration (MIC) = 1000 μg/ml). On the other hand, DA-EO at 25 and 12.5 μg/ml presented remarkable schistosomicidal action in vitro and killed 100% of adult worm pairs within 24 and 72 h, respectively. The LC50 values of DA-EO were 6.50 ± 0.38, 3.66 ± 1.06, and 3.65 ± 0.76 μg/ml at 24, 48, and 72 h, respectively. However, DA-EO at concentrations higher than 312.5 μg/ml significantly reduced the viability of GM07492-A cells (IC50  = 207.1 ± 4.4 μg/ml). The selectivity index showed that DA-EO was 31.8 times m...Continue Reading

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Citations

Feb 19, 2020·Phytotherapy Research : PTR·Muhammad Torequl IslamJavad Sharifi-Rad
May 14, 2018·Chemistry & Biodiversity·Herbert J DiasAntônio E M Crotti
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz Jardelino de Lacerda NetoFrancisco Assis Bezerra da Cunha

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