Chemical composition, antimicrobial and antitumor activities of the essential oils and crude extracts of Euphorbia macrorrhiza.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jianbo LinHaji Akber Aisa

Abstract

The present study aimed to examine the chemical composition and biological activity of essential oils extracted from Euphorbia macrorrhiza collected from Northwest China. The major constituents of the essential oils of aerial parts and roots of E. macrorrhiza are acorenone B (16.72% and 25.80%), (+)-cycloisosativene (14.94% and 12.40%), 3a-hydroxy-5b-androstane (10.62% and 5.52%), copaene (7.37% and 6.29%), l-calamenene (4.13% and 4.65%) and β-cedrene (8.40% and 7.98%), respectively. The minor components of them are thymene, γ-terpinene, thymecamphor, α-cedrene, zingiberene, trans-caryophyllene, β-chamigrene, curcumene, pentadecane, (-)-α-muurolene, cuparene, γ-cadinene, (Z)-3-heptadecene, 1,3,7,7-tetramethyl-2-oxabicyclo(4.4.0)dec-5-en-4-one, hexahydrofarnesyl acetone, γ-elixene and palmitinic acid. The antimicrobial and antitumor activitiy of the E. macrorrhiza essential oil against Staphyloccocus aureus, Escherichia coli, Canidia Albicans and Caco-2 cells were evaluated. Among all the tested microorganisms and Caco-2 cells, the essential oils showed the strongest inhibitory effect on Staphyloccocus aureus (MIC = 2.8 μg/mL) and Caco-2 cell (IC₅₀ = 11.86 μg/mL), whereas no effect on Escherichia coli and Candida albicans. The d...Continue Reading

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Citations

Jan 10, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan ChenCongyan Liu
Feb 26, 2016·Journal of Ethnopharmacology·Lívia Eidam Camargo LuzFlávio Luís Beltrame
Dec 27, 2015·Phytochemistry·Jie GaoHaji Akber Aisa
Jun 18, 2016·BioMed Research International·Maria Barbara PisanoFrancesca Pintus
Nov 3, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li CuiXiao-Bin Jia
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hanaa H AhmedSoheir E Kotob
Feb 9, 2017·World Journal of Microbiology & Biotechnology·Cynthia MalhadasPaula Baptista
Mar 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Han-Yu ZhangPeng-Xiang Lai
Jan 1, 2015·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Shengjie YangSong Yang
Dec 31, 2019·International Journal of Analytical Chemistry·Muhammad Nasimullah QureshiHaji Akber Aisa

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