Chemical composition, antioxidant and cytotoxic activities of extracts from the leaves of Smilax brasiliensis Sprengel (Smilacaceae)

Natural Product Research
Paula Avelar AmadoLuciana Alves Rodrigues Dos Santos Lima

Abstract

The antioxidant and cytotoxic activities of petroleum ether and methanol extracts, fatty acids and methyl esters from leaves of Smilax brasiliensis were evaluated, and the composition of the extracts was determined. Palmitic, linoleic and linolenic acids were major components of the extracts. For antioxidant activity, all samples exhibited IC50values lower than BHT (2,6-di-tert-butyl-4-methylphenol). The extracts, fatty acids and methyl esters from S. brasiliensis presented no toxicity to larvae of the brine shrimp, Artemia salina. Among the purified substances, only methyl linolenate showed toxicity (LD50 = 21.47 μg/mL). This study showed, for the first time, the composition of petroleum ether and methanol extracts from S. brasiliensis leaves, as well as the antioxidant and cytotoxic activities of extracts, fatty acids and methyl esters.

References

May 1, 1982·Planta medica·B N MeyerJ L McLaughlin
Mar 19, 2013·Journal of Ethnopharmacology·Ulrike B BreitbachMaria G L Brandão
Feb 4, 2014·Natural Product Research·Jing XuCunli Zhang
Apr 9, 2014·Natural Product Research·Marcela Isis MoraisLuciana Alves Rodrigues dos Santos Lima

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Citations

Jan 3, 2019·Natural Product Research·Paula Avelar AmadoLuciana Alves Rodrigues Dos Santos Lima
Jun 9, 2019·Natural Product Research·Myriam Almeida BarbosaLuciana Alves Rodrigues Dos Santos Lima
Feb 18, 2020·Ecotoxicology and Environmental Safety·Paula Avelar AmadoLuciana Alves Rodrigues Dos Santos Lima
Nov 30, 2021·Natural Product Research·Bing SunAi-Qun Jia

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