Chemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan

BMC Complementary and Alternative Medicine
Sajjad AhmadMuhammad Raza Shah

Abstract

Ethnomedicinally Rumex hastatus D. Don has been used since long for various ailments especially in neurological disorders. The reported data and the importance of Rumex genus demonstrate the vital medicinal value of R. hastatus. In the current investigational study, isolation of essential oil and its antioxidant and anticholinesterase assays were performed. The essential oil of R. hastatus was analyzed by GC-MS for the first time. The essential oil was evaluated for anticholinesterase and antioxidant assays. The anticholinesterase assay was conducted at various concentrations (62.5 to 1000 μg/ml) against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Similarly, the antioxidant potential was determined using DPPH and ABTS free radicals. The GC-MS analysis of essential oil showed 123 components. The result recorded for the anticholinesterase assays demonstrated a marked potential against AChE and BChE with IC50 values of 32.54 and 97.38 μg/ml respectively which were comparable with the positive control i.e., galanthamine (AChE, IC50 = 4.73 μg/ml and BChE, IC50 = 11.09 μg/ml). The antioxidant assays against DPPH and ABTS free radicals also exhibited significant scavenging potential with IC50 values of 3.71 and 6.29 ...Continue Reading

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Citations

Sep 1, 2015·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram Shah
Oct 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan-Dan ZhaoYan-Long Zhang
Dec 7, 2016·BMC Complementary and Alternative Medicine·Muhammad AyazAnwar Zeb
Mar 22, 2018·Pharmaceutical Biology·Hafiz Misbah-Ud-Din QamarAbdul Jabbar Shah
Jan 12, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Muhammad ZahoorIrfan Khan
Nov 9, 2018·Frontiers in Aging Neuroscience·Muhammad OvaisZabta Khan Shinwari
Jun 15, 2017·Frontiers in Aging Neuroscience·Muhammad AyazJawad Ahmed
Jan 4, 2018·BMC Complementary and Alternative Medicine·Muhammad OvaisZabta Khan Shinwari
May 15, 2018·Frontiers in Pharmacology·Hammad Ullah, Haroon Khan
Nov 9, 2018·Frontiers in Pharmacology·Thaiane Coelho Dos SantosAntonio Marcus de Andrade Paes
Jan 5, 2019·BMC Complementary and Alternative Medicine·Tanzeel ZohraMohammad Zahoor
Oct 24, 2017·Frontiers in Pharmacology·Muhammad AyazSajjad Ahmad
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aysegul Mutlu-IngokEsra Capanoglu
Aug 17, 2018·Mitochondrial DNA. Part B, Resources·Lingjian GuiYingying Liu
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd RashedDevi Nair Gunasegavan Rathi

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