Chemical composition of cold-pressed blackberry seed flour extract and its potential health-beneficial properties

Food Science & Nutrition
Uyory ChoeLiangli Lucy Yu

Abstract

The blackberry seed flour was cold-extracted using 50% acetone and examined for its phytochemical composition and health-beneficial properties including in vitro gut microbiota modulatory, free radical scavenging, anti-inflammatory, and antiproliferative capacities. Among identified thirteen components of blackberry seed flour extract through UHPLC-MS analysis, sanguiin H6 was the primary component and followed by ellagic acid and pedunculagin. For health-beneficial properties, the blackberry seed flour extract increased the total number of gut bacteria and shifted the abundance of specific bacterial phylum, family, or genus. The extract had RDSC, ORAC, HOSC, and ABTS•+ scavenging capacities of 362, 304, 2,531, and 267 μmol Trolox equivalents (TE)/g, respectively. In addition, the blackberry seed flour extract showed capacities for anti-inflammation and antiproliferation by suppressing LPS induced IL-1β mRNA expressions in the cultured J774A.1 mouse macrophages and the proliferation of LNCaP prostate cancer cells. The results suggest potential health benefits and further utilization of blackberry seed flour as functional foods.

References

Dec 23, 2004·Journal of Agricultural and Food Chemistry·B Shaun BushmanSteven J Knapp
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Feb 2, 2006·Journal of Agricultural and Food Chemistry·Jeffrey MooreLiangli Lucy Yu
May 25, 2006·Journal of Agricultural and Food Chemistry·John ParryLiangli Lucy Yu
Jul 20, 2006·Journal of Agricultural and Food Chemistry·Zhihong ChengLiangli Lucy Yu
Sep 28, 2006·Journal of Agricultural and Food Chemistry·Zhihong ChengLiangli Yu
Nov 23, 2006·Journal of Agricultural and Food Chemistry·Jeffrey MooreLiangli Lucy Yu
Nov 6, 2007·The British Journal of Nutrition·Xenofon TzounisJeremy P E Spencer
Jan 24, 2008·Journal of Agricultural and Food Chemistry·Tiffany J HagerRonald L Prior
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Feb 21, 2009·Journal of Agricultural and Food Chemistry·Mar LarrosaJuan Carlos Espín
May 14, 2009·Molecular Nutrition & Food Research·Antonio González-SarríasMaría-Teresa García-Conesa
Aug 27, 2009·Journal of Agricultural and Food Chemistry·Dobroslawa BialonskaDaneel Ferreira
Mar 2, 2010·International Journal of Food Sciences and Nutrition·Manoj KumarHariom Yadav
May 11, 2010·International Journal of Food Microbiology·Dobroslawa BialonskaDaneel Ferreira
May 11, 2012·Gut Microbes·Harry J FlintEvelyne Forano
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Oct 25, 2012·Current Pharmaceutical Design·Luca VanellaValeria Sorrenti
Jan 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pedro MenaDaniele Del Rio
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Oct 3, 2013·Oncology Reports·Luca VanellaValeria Sorrenti
May 18, 2016·Toxins·Tariq IsmailPiero Sestili
Jul 6, 2016·Frontiers in Microbiology·Amy O'Callaghan, Douwe van Sinderen
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Quinatzin Y Zafra-RojasEsther Ramírez-Moreno
Aug 22, 2017·Frontiers in Microbiology·María V SelmaFrancisco A Tomás-Barberán
Jan 10, 2018·Frontiers in Immunology·Matthew ClarkRoland M Tisch
May 8, 2018·Annals of Neurology·Monica S SpychalaLouise D McCullough

❮ Previous
Next ❯

Citations

Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elina PuljulaMaarit Karonen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Scientific Xcalibur
GraphPad
Thermo
QualBrowser
PRISM8

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.