Abstract
Eight amides, pellitorine (1), guineensine (2), brachystamide B (3), sarmentine (4), brachyamide B (5), 1-piperettyl pyrrolidine (6), 3',4',5'-trimethoxycinnamoyl pyrrolidine (7) and sarmentosine (8), two lignans, (+)-asarinin (9) and sesamin (10), and four other compounds, 1-(3,4-methylenedioxyphenyl)-1E-tetradecene (11), methyl piperate (12) and a mixture of beta-sitosterol (13) and stigmasterol (14), were isolated from the fruits of Piper sarmentosum (Piperaceae). This is the first reported isolation of compounds 2, 3, 5, 6, 7, 9, 10 and 12 from this plant species. Their structures were established from spectral data. These compounds were evaluated in antituberculosis and antiplasmodial tests. The results showed that compounds 4 and 6 exhibited both activities while compounds 1, 2, 5, 8 and 11 showed only antituberculosis activity. This is the first report of the antituberculosis and antiplasmodial activities for these compounds.
References
Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Aug 20, 1976·Science·W Trager, J B Jensen
Apr 9, 1998·Journal of Ethnopharmacology·P PeungvichaS Kadota
Jul 31, 1998·Journal of Ethnopharmacology·W RidtitidM Sunbhanich
Jun 11, 1999·Journal of Ethnopharmacology·N Najib Nik A RahmanM Ali Mohd
Jan 30, 2007·Planta medica·J R StöhrR Bauer
Apr 1, 1989·Planta medica·A KijjoaW Herz
Citations
Oct 7, 2011·Journal of Natural Products·Li PanA Douglas Kinghorn
Feb 26, 2010·Journal of Asian Natural Products Research·Kooi-Mow SimLi-Ping Ho
Feb 24, 2009·Natural Product Research·K HussainP Ibrahim
Oct 8, 2009·Natural Product Research·G C L EeC F J Bong
May 2, 2013·Journal of Medicinal Food·Hanaa H AhmedSoheir E Kotob
Apr 19, 2011·BMC Complementary and Alternative Medicine·Azizah UgusmanNor Anita Megat Mohd Nordin
Mar 5, 2009·Cancer Cell International·Shahrul Hisham Zainal AriffinRohaya Megat Abdul Wahab
Nov 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan David Guzman
May 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Julia B AlthausThomas J Schmidt
Dec 29, 2009·Journal of Ethnopharmacology·Z A ZakariaM R Sulaiman
Jun 11, 2009·Journal of Ethnopharmacology·Céline ValadeauGeneviève Bourdy
Oct 22, 2008·Journal of Ethnopharmacology·E LautiéM-L Villarreal
Aug 19, 2007·Pharmacology & Therapeutics·George A GaleVanicha Vichai
Mar 18, 2016·Tropical Animal Health and Production·Dingfa WangGuanyu Hou
Jul 25, 2009·Medicinal Research Reviews·Arvind S NegiSuman P S Khanuja
Nov 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Mas Rizal Ab RahmanMarina Mohd Bakri
Nov 26, 2010·Journal of Ethnopharmacology·Suriyati MohamadSiti Suraiya Md Noor
Apr 10, 2014·Journal of Oleo Science·Le D HieuIsiaka A Ogunwande
Apr 24, 2015·Frontiers in Plant Science·Franck E DayanLouis G Boddy
Aug 6, 2014·TheScientificWorldJournal·Azizah UgusmanZaleha Abdullah Mahdy
Aug 6, 2016·BioMed Research International·Lieselotte VeryserBart De Spiegeleer
Mar 21, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Wej ChoochoteBenjawan Pitasawat
Jun 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Harley da Silva AlvesMaria Célia de Oliveira Chaves
Dec 24, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa da Silva CarraraDiógenes Aparício Garcia Cortez
Mar 2, 2019·Current Alzheimer Research·Elaine Wan Ling ChanSook Yee Gan
Apr 11, 2012·Pharmaceutical Biology·Khalid HussainAmirin Sadikun
Oct 20, 2018·Current Computer-aided Drug Design·Mahmoud RayanAnwar Rayan
Oct 31, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Shuaibu Babaji SanusiMuhammad Murtala Mainasara
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiWilliam N Setzer
Aug 4, 2018·Natural Products and Bioprospecting·Meng-Yuan XiaYue-Hu Wang
May 8, 2018·International Journal of Molecular Sciences·Wen-Hui PanHong-Jie Zhang
Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Fatimatuzzahra Hashim FauzyTaher F T Elshami
Jun 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan QianLuqi Huang
Dec 29, 2020·Journal of Ethnopharmacology·Dingfa WangGuanyu Hou
Feb 12, 2020·Heliyon·Sharifah Farhana Syed-Ab-RahmanDzolkhifli Omar
Oct 23, 2020·International Journal of Molecular Sciences·Siti Fadziyah Mohamad AsriElvy Suhana Mohd Ramli
Nov 3, 2020·Journal of Ethnopharmacology·A Anand GanapathyAlaganandam Kumaran
Sep 16, 2010·Journal of Agricultural and Food Chemistry·Huazhang HuangPamela G Marrone
Oct 20, 2010·Journal of Natural Products·Billy Joel CabanillasNicolas Fabre
Oct 6, 2021·Tropical Animal Health and Production·Fareed Uddin MemonHongbin Si