Chemical constituents and in vitro anti-inflammatory activity of Cistanche violacea Desf. (Orobanchaceae) extract

Fitoterapia
Amina BougandouraFadila Benayache

Abstract

A new iridoid (1) and a new phenylethanoid glycoside (4), together with five known compounds (2, 3, 5, 6 and 7), were isolated for the first time from the ethyl acetate soluble part of the hydroalcoholic extract of the aerial parts of Cistancheviolacea Desf. (Orobanchaceae), an endemic species of the North of the Sahara. The structures of these compounds have been elucidated on the basis of extensive 2D NMR spectroscopic analysis, including COSY, TOCSY, NOESY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY. All compounds were isolated from C. violacea for the first time. The anti-inflammatory activity of the EtOAc extract of C. violacea, was investigated by using human red blood cell (HRBC) membrane stabilization and inhibition of the albumin denaturation method. This study demonstrates, for the first time the effectiveness of C. violacea in combating inflammation, this might be believed to be influenced by the synergistic action of the above isolated compounds. The present study suggests that C. violacea would serve as a source for the discovery of novel anti-inflammatory agents.

References

Mar 1, 1968·The Journal of Pharmacy and Pharmacology·Y Mizushima, M Kobayashi
Jun 1, 1994·Planta medica·M C RecioJ L Ríos
Mar 21, 1998·Journal of Ethnopharmacology·M C Lu
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Edward R Sherwood, Tracy Toliver-Kinsky
May 3, 2006·The American Journal of Pathology·Raquel Soares, Isabel Azevedo
Aug 16, 2006·Bioorganic & Medicinal Chemistry·Masayuki YoshikawaOsamu Muraoka
May 14, 2008·Mini Reviews in Medicinal Chemistry·Rosa TundisFrancesco Menichini
Aug 12, 2008·Journal of Chromatography. a·Yong Jiang, Peng-Fei Tu
Jul 18, 2009·Phytotherapy Research : PTR·Run-Lan CaiYun Qi
Oct 12, 2010·Chemical & Pharmaceutical Bulletin·Toshio MorikawaOsamu Muraoka
Jun 20, 2012·Natural Product Research·Brigida D'AbroscaAntonio Fiorentino
Jul 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lifeng HanXiumei Gao
Dec 12, 2012·The American Journal of Chinese Medicine·Tian WangWenyan Xie
Jan 12, 2013·Science·Ira Tabas, Christopher K Glass

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Citations

Aug 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhenzhen Xue, Bin Yang
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasmine ChemamFadila Benayache
Jan 19, 2018·Aging and Disease·Ningqun WangXianglan Jin
Aug 4, 2020·Chemical & Pharmaceutical Bulletin·Huibo LeiWeidong Zhang
Feb 21, 2021·Journal of Ethnopharmacology·Leandro FerriniMaría Victoria Aguirre

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