Chemical Constituents, Antioxidant, Cyclooxygenase Inhibitor, and Cytotoxic Activities of Teucrium pruinosum Boiss. Essential Oil

BioMed Research International
Nidal JaradatReem Speih

Abstract

In traditional medicine, many pharmacological activities have already been ascribed to the genus of Teucrium plant. These include antirheumatic antispasmodic, anthelmintic, diuretic, hypoglycemic, and anticancer effects. The recent investigation aimed to characterize and estimate the chemical composition, anti-inflammatory, antioxidant, and anticancer potentials of the essential oil isolated by the microwave-ultrasonic apparatus from Teucrium pruinosum leaves collected from Palestine. The essential oil (EO) was analyzed by Gas Chromatography equipped with mass spectrometry (GC-MS), while its anticancer activity was evaluated against HeLa cervical adenocarcinoma cells. The ability of T. pruinosum EO to inhibit the conversion of Arachidonic Acid (AA) to PGH2 by ovine COX-1 and human recombinant COX-2 was determined using a COX inhibitor screening assay. In addition, the antioxidant activity of the EO was evaluated on the basis of the scavenging activity with a stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, while Trolox was used as a positive control. Forty-four molecules were identified in T. pruinosum EO, representing 100% of the total EO. Agarospirol was found to be the most abundant component (45.53%) followed by caryophy...Continue Reading

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Citations

Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sihao GuTong Zhang
Mar 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Neena Gopinathan PanickerFarah Mustafa
Oct 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nidal Jaradat, Nawaf Al-Maharik
Dec 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Nawaf Al-MaharikNour Emwas

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BETA
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ELISA

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BioDataFit

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