Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs)

Bioorganic & Medicinal Chemistry Letters
Le Duc DatYoung Ho Kim

Abstract

Chemical investigation of Kandelia candel resulted in the isolation of 19 compounds (1-19), including one new sesquiterpene glycoside, kandelside (1), three megastigman glycoside compounds (7-9), 16 known phenolic compounds (2-6 and 10-19). Structures of the isolated compounds were elucidated based on spectral data comparison with reported values. Isolated compounds were also evaluated for their inhibitory effects on the production of pro-inflammatory cytokines interleukin (IL)-12 p40, IL-6, and tumor necrosis factor α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among these compounds, compound 9 exhibited strong inhibitory activity against IL-6 production (IC50=0.07 ± 0.05 μM) and moderate inhibitory activity against TNF-α production (IC50=49.86 ± 1.02 μM), but exhibited no activity on IL-12 p40 production. Compounds 5 and 6 significantly inhibited IL-12 p40, IL-6, and TNF-α production with IC50 values of 11.68 ± 0.38, 44.52 ± 1.08, and 28.73 ± 0.96 μM, respectively.

References

Feb 6, 1999·Phytochemistry·M A Beck, H Häberlein
Dec 17, 2002·Phytochemistry·Kohei KazumaMasahiko Suzuki
Dec 20, 2002·Nature·Carl Nathan
Jan 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang-Liang ZhangJia-Hong Chen

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Citations

Nov 17, 2017·Natural Product Research·Le Ba VinhYoung Ho Kim
Jul 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liping ChengZhaocheng Ma
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep

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