PMID: 11933020Apr 5, 2002Paper

Chemical control of phospholipid distribution across bilayer membranes

Medicinal Research Reviews
J Middleton Boon, Bradley D Smith

Abstract

Most biological membranes possess an asymmetric transbilayer distribution of phospholipids. Endogenous enzymes expend energy to maintain the arrangement by promoting the rate of phospholipid translocation, or flip-flop. Researchers have discovered ways to modify this distribution through the use of chemicals. This review presents a critical analysis of the phospholipid asymmetry data in the literature followed by a brief overview of the maintenance and physiological consequences of phospholipid asymmetry, and finishes with a list of chemical ways to alter phospholipid distribution by enhancement of flip-flop.

References

Jul 1, 1976·Chemistry and Physics of Lipids·G V Marinetti, R Love
Mar 1, 1977·The Journal of Cell Biology·O S Nilsson, G Dallner
Jan 1, 1975·The Journal of Membrane Biology·S E GordeskyR Love
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SundlerP R Vagelos
Jan 1, 1979·Annual Review of Biochemistry·J A Op den Kamp
Mar 5, 1977·Journal of Molecular Biology·J E Rothman, E P Kennedy
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J E Rothman, E P Kennedy
Mar 21, 1978·Biochimica Et Biophysica Acta·E J van ZoelenL L van Deenen
May 4, 1978·Biochimica Et Biophysica Acta·C W HaestB Deuticke
Jun 2, 1978·Biochimica Et Biophysica Acta·B de KruijffL L van Deenen
Aug 1, 1978·Journal of Bacteriology·J C PatonW H Elliott
Jul 20, 1976·Biochimica Et Biophysica Acta·E J Lugtenberg, R Peters
Jan 21, 1977·Biochimica Et Biophysica Acta·O S Nilsson, G Dallner
Nov 1, 1977·Biochimica Et Biophysica Acta·J A Higgins, R M Dawson
Nov 30, 1992·Annals of the New York Academy of Sciences·D L DalekeM Zimmerman
Apr 1, 1992·European Journal of Biochemistry·F BasséA Bienvenüe
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B Chérif-ZaharY Colin
Dec 24, 1991·Biochemistry·J C McIntyre, R G Sleight
Jun 12, 1985·Biochimica Et Biophysica Acta·G Daum

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Citations

Jan 1, 2002·The Arabidopsis Book·Uwe Ludewig, Wolf B Frommer
Apr 19, 2011·Apoptosis : an International Journal on Programmed Cell Death·Bryan A SmithBradley D Smith
Apr 3, 2004·Biophysical Chemistry·Mario SuwalskyCarlos P Sotomayor
Apr 28, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SuwalskyP Zatta
Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SuwalskyC P Sotomayor
Dec 10, 2002·Current Opinion in Chemical Biology·J Middleton Boon, Bradley D Smith
Mar 9, 2010·Chemical Reviews·Renatus W SinkeldamYitzhak Tor
Jul 13, 2006·Journal of the American Chemical Society·Christopher C ForbesBradley D Smith
Jul 10, 2012·Chemical Communications : Chem Comm·Adam J PlauntBradley D Smith
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sophie PautotD A Weitz
Jul 13, 2012·The Journal of Biological Chemistry·Supriyo RayKen Teter
Apr 13, 2012·Molecular Biology of the Cell·Jason G KaySergio Grinstein
Sep 29, 2004·Journal of Virology·David A Coil, A Dusty Miller
Aug 17, 2005·Journal of Virology·David A Coil, A Dusty Miller
Nov 21, 2007·PLoS Computational Biology·Peter M Kasson, Vijay S Pande
Feb 10, 2012·Sensors·Jason G Kay, Sergio Grinstein
Apr 29, 2005·Journal of Pharmaceutical Sciences·Trudy RodgersMalcolm Rowland
Jan 17, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Janine BrodaWolfgang Wenzel
Jan 27, 2016·The Journal of Membrane Biology·Mario SuwalskyMarcela Manrique-Moreno
Jan 8, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Catarina Pereira-LeiteSalette Reis
Jun 29, 2010·Biochemical and Biophysical Research Communications·Mario SuwalskyPaolo Zatta
Aug 9, 2008·International Journal of Pharmaceutics·Mario SuwalskyCarlos P Sotomayor
Oct 4, 2014·Virology·Sven Moller-Tank, Wendy Maury
Jun 15, 2014·The Journal of Membrane Biology·Mario Suwalsky, Marcia Avello
Feb 15, 2005·Journal of Photochemistry and Photobiology. B, Biology·M SuwalskyJ Kiwi
Sep 12, 2006·Trends in Cell Biology·P A Janmey, P K J Kinnunen
Jul 18, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mario SuwalskyCarlos P Sotomayor
May 24, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SuwalskyC P Sotomayor
Nov 21, 2015·Biophysical Journal·Sebastian Fiedler, Heiko Heerklotz
Jun 26, 2013·Virus Research·Eric HastieValery Z Grdzelishvili
Jul 30, 2011·Biochimica Et Biophysica Acta·Marcela Manrique-MorenoMario Suwalsky

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