PMID: 6968734Aug 1, 1980Paper

Chemical damage in gamma-irradiated human erythrocyte membranes

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
S C PurohitR B Cundall

Abstract

In air saturated suspensions of erythrocyte ghost membranes gamma-irradiation causes formation of lipid peroxides, measured as malonaldehyde, and a loss of membrane protein sulphydryl groups. Addition of N-(p-amino-benzoyl)-1-glutamate prevented peroxidation up to doses of 2 x 10(3) Gy, due to scavenging of hydroxyl radicals. Another hydroxyl scavenger sodium formate, also prevented peroxidation at low doses, but lost its protective effect at higher doses probably because of secondary reactions of the resulting superoxide radical anion. Two sulphur containing radioprotectants also were able to reduce the extent of lipid peroxidation. The enzymes catalase and superoxide dismutase were added to the irradiated suspensions in order to determine the contribution from hydrogen peroxide and superoxide to peroxidation. The extents of peroxidation are compared with structural modification of the membrane under the same conditions of irradiation.

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Citations

Apr 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S I AyeneP N Srivastava
May 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W Leyko, G Bartosz
Apr 1, 1986·Seminars in Nuclear Medicine·R F Schmelter
Jan 1, 1987·Radiation and Environmental Biophysics·L SportelliC Cametti
Jan 1, 1994·Radiation and Environmental Biophysics·K SchwenkeL E Feinendegen
Jan 1, 1994·Radiation and Environmental Biophysics·A KöllingH A Diehl
Aug 10, 2000·Radiation Research·J HannigR C Lee
Feb 18, 2011·The Journal of Membrane Biology·Subramaniam Chitra, Chennam Srinivasulu Shyamaladevi
Feb 13, 2019·Physiological Reports·Barbora KaločayováNorbert Vrbjar
Aug 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S C PurohitR B Cundall
Jan 1, 1987·Free Radical Biology & Medicine·J GuilleJ M Gebicki

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