PMID: 9439983Jan 1, 1997Paper

Chemical degradation of wastes of antineoplastic agents. 2: Six anthracyclines: idarubicin, doxorubicin, epirubicin, pirarubicin, aclarubicin, and daunorubicin

International Archives of Occupational and Environmental Health
M CastegnaroS Hansel

Abstract

Handling of genotoxic compounds commonly used in cancer chemotherapy generates contaminated wastes that require decontamination before disposal. Chemical methods are an alternative and/or a complement to incineration for the treatment of wastes and spills. As part of a program initiated by the International Agency for Research on Cancer (IARC), 3 chemical methods readily available in the hospital environment--sodium hypochlorite (NaOCl, 5.25%), hydrogen peroxide (H2O2, < or = 30%) and Fenton reagent (FeCl2, 2H2O; 0.3 g in 10 ml H2O2, 30%)--are being tested for the degradation of a total of 32 antineoplastic agents. The efficiency of degradation was monitored by high-pressure liquid chromatography. The mutagenicity of the degradation residues were tested by the Ames test using tester strains Salmonella typhimurium TA 97a, TA 98, TA 100, and TA 102 with and without an exogenous metabolic activation system. The first results obtained for the degradation of cyclophosphamide, ifosfamide, and melphalan have been published in this journal. The present manuscript reports the results of the investigation of a series of six anthracyclines (aclarubicin, daunorubicin, doxorubicin, epirubicin, idarubicin, and pirarubicin) commonly used in c...Continue Reading

Citations

Jul 22, 2016·Clinical Journal of Oncology Nursing·Seth Eisenberg
Mar 30, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Bruce W ChaffeeKimberly A Redic
Feb 23, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Nicolas SimonSandrine Fleury-Souverain
May 17, 2013·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sandrine Fleury-SouverainPascal Bonnabry
Mar 10, 2015·Journal of Occupational and Environmental Hygiene·Antje BöhlandtRudolf Schierl
Jan 3, 2018·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Seth Eisenberg
Oct 5, 2018·Arhiv za higijenu rada i toksikologiju·Susana ViegasMário Pádua
Dec 19, 2019·Annals of Work Exposures and Health·Nicolas SimonSandrine Fleury-Souverain
Sep 21, 2006·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sarah RobertsGraham J Sewell
Apr 25, 2012·International Archives of Occupational and Environmental Health·Laetitia Minh Mai LêEric Caudron

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