Chemical ecology of antibiotic production by actinomycetes

FEMS Microbiology Reviews
Anne van der MeijGilles P van Wezel

Abstract

Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural products relevant for agriculture, biotechnology and medicine, including the majority of the antibiotics we use in the clinic. Rather than as free-living bacteria, many actinomycetes have evolved to live in symbiosis with among others plants, fungi, insects and sponges. As a common theme, these organisms profit from the natural products and enzymes produced by the actinomycetes, for example, for protection against pathogenic microbes, for growth promotion or for the degradation of complex natural polymers such as lignocellulose. At the same time, the actinomycetes benefit from the resources of the hosts they interact with. Evidence is accumulating that these interactions control the expression of biosynthetic gene clusters and have played a major role in the evolution of the high chemical diversity of actinomycete-produced secondary metabolites. Many of the biosynthetic gene clusters for antibiotics are poorly expressed under laboratory conditions, but they are likely expressed in response to host-specific demands. Here, we review the environmental triggers and cues that control natural product formation by actinomycetes and provide po...Continue Reading

References

Jan 1, 1978·Annual Review of Microbiology·J C Ensign
Jan 1, 1992·Annual Review of Microbiology·S Horinouchi, T Beppu
Jun 1, 1992·Journal of Bacteriology·M LonettoC A Gross
Jun 15, 1992·Gene·E M WellingtonP R Herron
Feb 1, 1991·Molecular Microbiology·E StrauchM J Bibb
Jan 4, 1969·Nature·R R BurgessE K Bautz
Jun 1, 1970·Journal of General Microbiology·D A HopwoodH M Palmer
Jan 1, 1980·European Journal of Biochemistry·S BiróG Szabó
Jan 1, 1993·Annual Review of Microbiology·K F Chater
Nov 1, 1995·Journal of Bacteriology·H OnakaS Horinouchi
Jul 25, 1994·Molecular & General Genetics : MGG·S AngellM J Bibb
Jun 1, 1997·Molecular Microbiology·H Onaka, S Horinouchi
Aug 3, 1999·The EMBO Journal·J G KangJ H Roe
Feb 25, 2000·Nature·S RadajewskiJ C Murrell
Aug 17, 2000·Journal of Applied Microbiology·E A KatsifasA D Karagouni
Aug 31, 2000·Annual Review of Biochemistry·A M StockP N Goudreau
Nov 9, 2000·Molecular Microbiology·A CheggourC Goffin
Jun 21, 2001·The Quarterly Review of Biology·U G MuellerD Malloch
Jan 10, 2002·Journal of Industrial Microbiology & Biotechnology·S HorinouchiD K Kang
Apr 12, 2002·The Journal of Biological Chemistry·David C LambSteven L Kelly
Apr 27, 2002·Applied and Environmental Microbiology·Ranjeet K TokalaM J Morra
Jun 21, 2002·Advances in Microbial Physiology·John D Helmann
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ulrich G Mueller, Nicole Gerardo
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·A Sola-LandaJ F Martín
May 22, 2003·Microbes and Infection·Gary A Strobel

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Citations

May 10, 2017·FEMS Microbiology Reviews·Ehud BaninOscar P Kuipers
May 4, 2017·Chembiochem : a European Journal of Chemical Biology·Changsheng WuGilles P van Wezel
Feb 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Tobias EnglMartin Kaltenpoth
May 4, 2018·Natural Product Reports·Helga U van der HeulGilles P van Wezel
Apr 30, 2019·Nucleic Acids Research·Kai BlinTilmann Weber
Jan 21, 2020·Chemistry, an Asian Journal·Chao Liu, Hideaki Kakeya
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fleurdeliz MaglangitHai Deng
Jun 20, 2020·Microbiology·Samuel M M PrudenceThomas C McLean
Apr 17, 2020·Journal of Dental Research·S S MomeniH Wu
Sep 25, 2020·International Journal of Systematic and Evolutionary Microbiology·Jan W SchwitallaChristine Beemelmanns
Sep 17, 2020·MSystems·Pernille Kjersgaard BechMikael Lenz Strube
Jul 10, 2019·Annual Review of Phytopathology·Shree P ThapaJeff H Chang
May 23, 2020·Microbiology Resource Announcements·Anna TippeltM Soledad Vela Gurovic
Aug 18, 2020·International Journal of Microbiology·Denis V Axenov-GribanovMaxim A Timofeyev
Aug 28, 2020·Planta medica·Carla MenegattiMônica T Pupo
Jun 23, 2018·Applied Microbiology and Biotechnology·Marie-Ève Lacombe-HarveyCarole Beaulieu
Feb 8, 2019·Journal of Industrial Microbiology & Biotechnology·Nataliia V MachushynetsGilles P van Wezel
Jun 16, 2019·Pathogens·Jake T NewittSarah F Worsley
Dec 11, 2019·International Journal of Molecular Sciences·Elena Maria ColomboMatias Pasquali
Jun 3, 2020·Nature Reviews. Microbiology·Doris A van BergeijkGilles P van Wezel
May 13, 2020·Nature Microbiology·Shaohua GuAlexandre Jousset
Jul 18, 2020·International Journal of Microbiology·Risa NofianiTaifo Mahmud
Nov 2, 2017·Frontiers in Microbiology·Bernal Matarrita-CarranzaAdrián A Pinto-Tomas
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christopher M RangerJ Philipp Benz
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Gustavo BodelónIsabel Pastoriza-Santos
Jan 27, 2019·Journal of Industrial Microbiology & Biotechnology·Mohammad R Seyedsayamdost

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