PMID: 6977463Feb 1, 1982Paper

Chemical energy balance in amphibian and mammalian muscles

Federation Proceedings
M J Kushmerick, M T Crow

Abstract

A quantitative comparison of the utilization of creatine phosphate and ATP during a muscle contraction with the extent of recovery oxygen consumption afterward is used to establish a biochemical energy balance. In prolonged contractions of sartorii from Rana temporaria and in tetani of mouse hindlimb muscles, the predicted stoichiometric relationship, delta approximately P/delta O2 = 6.2, is observed. Thus a simple energetic paradigm of a separable contractile and recovery phase is quantitatively valid. In contrast, in brief contractions of sartorii of R. pipiens and R. temporaria, the ratio of delta approximately P/delta O2 is lower than the predicted value of 6.2. This biochemical energy imbalance observed in brief tetani of frog muscles implies: 1) a significant and continued utilization of high-energy phosphates after mechanical relaxation and 2) that measurement of high-energy phosphate utilization during contraction does not measure the total energy cost for the contraction. In the fast, pale, mouse extensor digitorum longus muscle, phosphorylation in an 18,000-dalton myosin light chain occurred during contraction and was correlated with twofold decrease in the isometric maintenance energy cost. Thus the energy cost for m...Continue Reading

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