Chemical evolution: from formamide to nucleobases and amino acids without the presence of catalyst.

Journal of Biomolecular Structure & Dynamics
Venelin EnchevNadezhda Markova

Abstract

Abiotic synthesis of nucleobases and amino acids is of critical importance as it sheds light on potential prebiotic chemical reactions. During thermal decomposition of formamide in vacuum conditions, purine, cytosine, adenine, hypoxanthine, uracil, pterin, urea, urocanic acid, glycine, alanine and norvaline were detected. The compounds were obtained without catalyst by heating at 100-180 °C or microwave heating of formamide. Reaction network of self-catalyzed chemical reactions is suggested, showing how from only one parent molecule, nucleobases, urea and the amino acid glycine can be produced. The reaction pathways are theoretically determined using SCS-MP2 calculations.Communicated by Ramaswamy H. Sarma.

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lukáš PeteraJudit Sponer

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Methods Mentioned

BETA
deamination
X-ray
thermal dissociation
neutron diffraction
NMR
Raman spectroscopy

Software Mentioned

GROMACS
GAMESS

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