Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla

European Radiology
Shuzhong ChenYì-Xiáng J Wáng

Abstract

To evaluate Chemical Exchange Saturation Transfer (CEST) MRI for liver imaging at 3.0-T. Images were acquired at offsets (n = 41, increment = 0.25 ppm) from -5 to 5 ppm using a TSE sequence with a continuous rectangular saturation pulse. Amide proton transfer-weighted (APTw) and GlycoCEST signals were quantified as the asymmetric magnetization transfer ratio (MTRasym) at 3.5 ppm and the total MTRasym integrated from 0.5 to 1.5 ppm, respectively, from the corrected Z-spectrum. Reproducibility was assessed for rats and humans. Eight rats were devoid of chow for 24 hours and scanned before and after fasting. Eleven rats were scanned before and after one-time CCl4 intoxication. For reproducibility, rat liver APTw and GlycoCEST measurements had 95 % limits of agreement of -1.49 % to 1.28 % and -0.317 % to 0.345 %. Human liver APTw and GlycoCEST measurements had 95 % limits of agreement of -0.842 % to 0.899 % and -0.344 % to 0.164 %. After 24 hours, fasting rat liver APTw and GlycoCEST signals decreased from 2.38 ± 0.86 % to 0.67 ± 1.12 % and from 0.34 ± 0.26 % to -0.18 ± 0.37 % respectively (p < 0.05). After CCl4 intoxication rat liver APTw and GlycoCEST signals decreased from 2.46 ± 0.48 % to 1.10 ± 0.77 %, and from 0.34 ± 0.23 % t...Continue Reading

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Citations

Jan 23, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zheng Han, Guanshu Liu
Jan 22, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jinyuan ZhouShanshan Jiang
Jul 11, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lu YuMin Chen
Apr 20, 2020·Abdominal Radiology·Hilton Leao FilhoNatally Horvat
Mar 20, 2021·Journal of Magnetic Resonance Imaging : JMRI·Diana M LindquistJonathan R Dillman
Dec 5, 2021·Insights Into Imaging·Michele GaetaCarmela Visalli

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